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Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes
(Public Library Of Science (PLOS), 2011)
Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight
gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis ...
A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
(Public Library Of Science (PLOS), 2011)
The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a
117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a ...