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Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases
(MDPI, 2020)
Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the ...
Mechanisms of longevity extension and healthy aging by over-expression of cytochrome b5 reductase 3
(Universidad de Córdoba, UCOPress, 2021)
Introduction. Aging is a natural time-dependent process characterized by the accumulation of damage in cellular structures that compromises cellular and tissue function leading ultimately to the death of the organism. ...
Novel molecular insights on the role of splicing dysregulation in cancer
(Universidad de Córdoba, UCOPress, 2022)
Cancer and tumoral diseases represent one of most serious and complicated public health problems, being one of the leading causes of death in the world. The remarkable variety across cancer types, and the heterogeneity ...
Rab18 drift in lipid droplet and endoplasmic reticulum interactions of adipocytes under obesogenic conditions
(MDPI, 2023)
The adipose tissue stores excess energy in the form of neutral lipids within adipocyte lipid droplets (LDs). The correct function of LDs requires the interaction with other organelles, such as the endoplasmic reticulum ...
Identification of potential bioactive peptides in sheep milk kefir through peptidomic analysis at different fermentation times
(MDPI, 2023)
Sheep farming is an important socioeconomic activity in most Mediterranean countries, particularly Spain, where it contributes added value to rural areas. Sheep milk is used in Spain mainly for making cheese, but it can ...
Multi-organ increase in Norepinephrine levels after central leptin administration and diet-induced obesity
(MDPI, 2023)
Autonomic innervation is important to regulate homeostasis in every organ of the body. The sympathetic nervous system controls several organs associated with metabolism and reproduction, including adipose tissue, the liver, ...
A genome-wide association study of mare fertility in the Pura Raza Español horse
(Elsevier, 2022)
Despite the economic importance of fertility for the horse industry, few efforts have been made to achieve a better understanding of the genetic mechanisms underlying its control. This is probably due to the difficulty of ...
MicroRNAs and GRK2 as modulators of Kiss1/GPR54 system: Physiopathological role in pubertal alterations and obesity induced hypogonadism
(Universidad de Córdoba, UCOPress, 2023)
The reproductive function is governed by the so-called hypothalamic-pituitary-gonadal (HPG) axis, where an intricated network of central, peripheral and external factors determine hormonal balance and proper functioning ...
Synergistic antibacterial effects of amoxicillin and gold nanoparticles: a therapeutic option to combat antibiotic resistance
(MDPI, 2023)
Compacted Au@16-mph-16/DNA-AMOX (NSi) nanosystems were prepared from amoxicillin (AMOX) and precursor Au@16-mph-16 gold nanoparticles (Ni) using a Deoxyribonucleic acid (DNA) biopolymer as a glue. The synthesized nanocarrier ...
Novel regulatory mechanisms of Kiss1 neurons during reproductive axis development and in conditions of metabolic stress: Analysis of the roles of microRNAs and elements of the secretory pathway
(Universidad de Córdoba, UCOPress, 2023)
Reproduction is indispensable for the perpetuation of the species. Therefore, it is safeguarded by a sophisticated network of regulatory mechanisms that ultimately controls the reproductive function by modulating the ...