Listar Departamento de Ciencias Médicas y Quirúrgicas por autor "5555dd0e-560b-4e17-a5ab-a41864b9d964"
Mostrando ítems 21-40 de 46
-
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
Marín, Carmen; Yubero-Serrano, Elena M.; Pérez-Jiménez, Francisco; López-Miranda, José (MDPI, 2013)Aging is a condition which favors the development of atherosclerosis, which has been associated with a breakdown in repair processes that occurs in response to cell damage. The dysregulation of the biological systems ... -
Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study
Cruz‐Ares, Silvia de la; Cardelo, Magdalena P.; Gutiérrez Mariscal, Francisco Miguel; Torres‑Peña, J.D.; García-Ríos, Antonio; Katsiki, Niki; Malagón, María M.; López-Miranda, José; Pérez-Martínez, Pablo; Yubero-Serrano, Elena M. (MDPI, 2020)Endothelial dysfunction and intima-media thickness of common carotid arteries (IMT-CC) are considered subclinical markers of atherosclerotic cardiovascular disease (ASCVD). Advanced glycation end products (AGEs) are increased ... -
Epidemiologic Behavior of Obesity in the Maracaibo City Metabolic Syndrome Prevalence Study
López-Miranda, José; Bermúdez Pirela, Valmore José; Pacheco, Maikol; Rojas, Joselyn; Córdova, Evelyn; Velázquez, Rossibel; Carrillo, Daniela; Parra, María G.; Toledo, Alexandra; Añez, Roberto; Fonseca, Eneida; París Marcano, Rafael; Cano, Clímaco; López-Miranda, José (Public Libray of Science (PLOS), 2012)Introduction: Obesity is a worldwide public health issue. Since the epidemiological behaviour of this disease is not well established in our country, the purpose of this study was to determinate its prevalence in the ... -
Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study
Martín-Piedra, Laura; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan Luis; Torres‑Peña, J.D.; Caballero-Villarraso, Javier; Luque, Raúl M.; Pérez-Martínez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2021)Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing ... -
Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
García-Ríos, Antonio; Mc Monagle, Jolene; Gulseth, Hanne L.; Ordovás, José María; Shaw, Danielle I.; Karlström, Brita; Kiec-Wilk, Beata; Blaak, Ellen E.; Helal, Olfa; Malczewska-Malec, Malgorzata; Defoort, Catherine; Risérus, Ulf; Saris, Wim H.M.; Lovegrove, Julie A.; Drevon, Christian A.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Roche, Helen M.; López-Miranda, José (Public Library Of Science (PLOS), 2011)Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism. Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose ... -
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
León Acuña, Ana; Delgado Lista, José; Torres‑Peña, J.D.; López Moreno, Javier; García-Ríos, Antonio; Marín, Carmen; Gómez Delgado, Francisco; Caballero, J.; Van‑Ommen, B.; Malagón, María M.; Pérez-Martínez, Pablo; Alcalá Díaz, Juan Francisco; Camargo García, A.; López-Miranda, José (BioMed Central, 2016)Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, ... -
Hypertriglyceridemia Influences the Degree of Postprandial Lipemic Response in Patients with Metabolic Syndrome and Coronary Artery Disease: From the Cordioprev Study
Alcalá Díaz, Juan Francisco; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Quintana-Navarro, Gracia M.; Gómez-Luna, Purificación; Camargo García, A.; Almadén Peña, Yolanda; Caballero, Javier; Marín, Carmen; García-Ríos, Antonio; Tinahones, Francisco J.; Ordovas, José M.; Pérez-Jímenez, Francisco; López-Miranda, José (PLOS, 2014)Objective To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria. Materials and Methods 1002 ... -
Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis
Monfort-Pires, Milena; Delgado-Lista, Javier; Gómez Delgado, Francisco; López-Miranda, José; Pérez-Martínez, Pablo; Gouvea Ferreira, Sandra Roberta (MDPI, 2016)Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the ... -
Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
Talavera-García, Eva; Delgado-Lista, Javier; García-Ríos, Antonio; Delgado-Casado, Nieves; Gómez-Luna, Purificación; Gómez-Garduño, Ángela; Gómez Delgado, Francisco; Alcalá Díaz, Juan Francisco; Yubero-Serrano, Elena M.; Marín, Carmen; Pérez-Caballero, Ana I.; Fuentes-Jiménez, Francisco J.; Rodríguez-Cantalejo, Fernando; Tinahones, Francisco J.; Ordovás, José María; Pérez-Jiménez, Francisco; Pérez-Martínez, Pablo; López-Miranda, José; Camargo García, A. (Public Library of Science, 2016)Background Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence ... -
Influence of Protein Carbonylation on Human Adipose Tissue Dysfunction in Obesity and Insulin Resistance
Navarro-Ruiz, Carmen; Soler-Vázquez, M. Carmen; Díaz-Ruiz, Alberto; Peinado, Juan R.; Nieto Calonge, Andrea; Sánchez Ceinos, Julia; Tercero-Alcázar, C.; López-Alcalá, J.; Rangel Zúñiga, Oriol Alberto; Membrives, Antonio; López-Miranda, José; Malagón, María M.; Gúzman-Ruiz, Rocío (MDPI, 2022)Background: Obesity is characterized by adipose tissue dysregulation and predisposes individuals to insulin resistance and type 2 diabetes. At the molecular level, adipocyte dysfunction has been linked to obesity-triggered ... -
Long-term effect of a dietary intervention with two-healthy dietary approaches on food intake and nutrient density in coronary patients: results from the CORDIOPREV trial
Cano‑Ibáñez, Naomi; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Yubero-Serrano, Elena M.; Pérez‑Corral, Isabel; Arenas de Larriva, Antonio P.; García-Ríos, Antonio; Pérez-Martínez, Pablo; Delgado-Lista, Javier; López-Miranda, José (Springer, 2022)Background: Cardiovascular disease (CVD) is the leading cause of disease burden in the world by non-communicable diseases. Nutritional interventions promoting high-quality dietary patterns with low caloric intake value and ... -
Mediterranean Diet and Endothelial Function: A Review of Its Effects at Different Vascular Bed Levels
Torres‑Peña, J.D.; Rangel Zúñiga, Oriol Alberto; Alcalá Díaz, Juan Francisco; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2020)The Mediterranean diet has recently been the focus of considerable attention as a palatable model of a healthy diet. Its influence on many cardiovascular risk factors, combined with its proven effect in reducing the risk ... -
NUTRITECH
López-Miranda, José (Oficina de Transferencia de Resultados de la Investigación, 2013)NutriTech is a European Commission funded FP7 research project (2012-2015) The goal of NutriTech is to quantify the effect of diet on “phenotypic flexibility”. Phenotypic flexibility extends on metabolic flexibility (the ... -
Owning a Pet Is Associated with Changes in the Composition of Gut Microbiota and Could Influence the Risk of Metabolic Disorders in Humans
Arenas-Montes, Javier; Pérez-Martínez, Pablo; Vals-Delgado, Cristina; Romero-Cabrera, Juan Luis; Cardelo, Magdalena P.; León Acuña, Ana; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; López-Miranda, José; Camargo García, A.; Pérez-Jiménez, Francisco (MDPI, 2021)Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis. We evaluated the influence of owning a pet ... -
Phenolic Content of Virgin Olive Oil Improves Ischemic Reactive Hyperemia in Hypercholesterolemic Patients
Ruano, Juan; López Miranda, José; Fuentes, Francisco; Moreno, Juan Antonio; Bellido, Cecilia; Pérez-Martínez, Pablo; Lozano, Aquiles; Gómez, Purificación; Jiménez, Yolanda; Pérez-Jiménez, Francisco (Elsevier, 2005)The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity. Background Endothelial-dependent vasodilatation is impaired during the postprandial state, and ... -
Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
Boughanem, Hatim; Yubero-Serrano, Elena M.; López-Miranda, José; Tinahones, Francisco J.; Macías-González, Manuel (MDPI, 2021)Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic ... -
Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids
Rangel Zúñiga, Oriol Alberto; Camargo García, A.; Marín, Carmen; Peña Orihuela, Judhit; Pérez-Martínez, Pablo; Delgado-Lista, Javier; González Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagón, María M.; Pérez-Jiménez, Francisco; Roche, Helen M.; López-Miranda, José (BioMed Central, 2015)Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including ... -
Quality and Quantity of Protein Intake Influence Incidence of Type 2 Diabetes Mellitus in Coronary Heart Disease Patients: From the CORDIOPREV Study
Cruz‐Ares, Silvia de la; Gutiérrez Mariscal, Francisco Miguel; Alcalá Díaz, Juan Francisco; Quintana-Navarro, Gracia M.; Podadera-Herreros, Alicia; Cardelo, Magdalena P.; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2021)Evidence suggests that enriching a diet with plant-based proteins could reduce the risk of developing type 2 diabetes mellitus. In the present work, we evaluated the association between the change in plant protein intake ... -
Telomere maintenance is associated with type 2 diabetes remission in response to a long-term dietary intervention without non-weight loss in patients with coronary heart disease: from the CORDIOPREV randomized controlled trial
Ojeda-Rodríguez, Ana; Alcalá Díaz, Juan Francisco; Rangel Zúñiga, Oriol Alberto; Arenas de Larriva, Antonio P.; Gutiérrez Mariscal, Francisco Miguel; Torres‑Peña, J.D.; Mora-Ortiz, Marina; Romero-Cabrera, Juan Luis; Luque, Raúl M.; Ordovas, José M.; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2024)In order to evaluate whether telomere maintenance is associated with type 2 diabetes remission, newly diagnosed type 2 diabetes patients without glucose-lowering treatment (183 out of 1002) from the CORDIOPREV study ... -
The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population
Pérez Martínez, Pablo; Pérez Jiménez, Francisco; Ordovás, José María; Bellido, Cecilia; Moreno, Juan; Gómez, Purificación; Marín, Carmen; Fernández de la Puebla, Rafael Ángel; Paniagua, Juan Antonio; López Miranda, José (Elsevier, 2007)Our goal was to determine whether the presence of the −516C/T polymorphism in the APOB gene promoter modifies the lipid response to changes in the amount and quality of dietary fat. We studied 97 young healthy volunteers ...