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Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health
(Public Library Of Science (PLOS), 2011)
Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to
pathway analysis, we have developed a joint multivariate and network-based approach to analysis ...
Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations
(Public Library Of Science (PLOS), 2012)
Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked
to higher cardiovascular risk. To date, there is little information about the additional impact of ...
Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
(Public Library Of Science (PLOS), 2011)
Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism.
Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose ...
NUTRITECH
(Oficina de Transferencia de Resultados de la Investigación, 2013)
NutriTech is a European Commission funded FP7 research project (2012-2015) The goal of NutriTech is to quantify the effect of diet on “phenotypic flexibility”. Phenotypic flexibility extends on metabolic flexibility (the ...
Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids
(BioMed Central, 2015)
Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease.
Its etiology is the result of a complex interaction between genetic and environmental factors, including ...
Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
(Public Library of Science, 2016)
Background
Recent data suggest that the presence of associated metabolic abnormalities may be
important modifiers of the association of obesity with a poorer prognosis in coronary heart
disease. We determined the influence ...
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
(BioMed Central, 2016)
Background/aims: Previous evidences have shown the presence of a prolonged and exaggerated postprandial
response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, ...
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
(MDPI, 2013)
Aging is a condition which favors the development of atherosclerosis, which has
been associated with a breakdown in repair processes that occurs in response to cell
damage. The dysregulation of the biological systems ...
Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis
(MDPI, 2016)
Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the ...
Epidemiologic Behavior of Obesity in the Maracaibo City Metabolic Syndrome Prevalence Study
(Public Libray of Science (PLOS), 2012)
Introduction: Obesity is a worldwide public health issue. Since the epidemiological behaviour of this disease is not well
established in our country, the purpose of this study was to determinate its prevalence in the ...