The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation
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Author
Martínez-Macías, M.I.
Córdoba-Cañero, Dolores
Rodríguez Ariza, Rafael
Roldán-Arjona, Teresa
Publisher
JBCDate
2013Subject
ArabidopsisDNA
Chromosomes
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Show full item recordAbstract
Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and
continued through a base excision repair pathway.
Results: XRCC1 stimulates ROS1-initiated demethylation and is required for efficient processing of post-excision
intermediates.
Conclusion: XRCC1 functions at several stages during active DNA demethylation.
Significance: This study identifies a new component of the active DNA demethylation pathway in Arabidopsis.