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Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats
dc.contributor.author | Raya, Ana I. | |
dc.contributor.author | Ríos, Rafael | |
dc.contributor.author | Pineda Martos, Carmen María | |
dc.contributor.author | Rodríguez-Ortiz, Maria E. | |
dc.contributor.author | Díez, Elisa | |
dc.contributor.author | Almadén Peña, Yolanda | |
dc.contributor.author | Muñoz-Castañeda, Juan R. | |
dc.contributor.author | Rodríguez, Mariano | |
dc.contributor.author | Aguilera Tejero, Escolástico | |
dc.contributor.author | López, Ignacio | |
dc.date.accessioned | 2018-12-07T11:21:47Z | |
dc.date.available | 2018-12-07T11:21:47Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://hdl.handle.net/10396/17560 | |
dc.description.abstract | Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function (Experiment 3, n = 12) were also fed NF or HF diets with high P (HP). Additionally, uremic (5/6Nx) rats (n = 16) were fed HP diets with NF or HF. Feeding the HF diets resulted in significant elevation of plasma FGF23 vs rats fed NF diets: Experiment 1, 593 ± 126 vs 157 ± 28 pg/ ml (p < 0.01); Experiment 2, 538 ± 105 vs 250 ± 18 pg/ml (p < 0.05); Experiment 3, 971 ± 118 vs 534 ± 40 pg/ml (p < 0.01). Rats fed HF diets showed P retention and decreased renal klotho (ratio klotho/actin) vs rats fed NF diets: Experiment 1, 0.75 ± 0.06 vs 0.97 ± 0.02 (p < 0.01); Experiment 2, 0.69 ± 0.07 vs 1.12 ± 0.08 (p < 0.01); Experiment 3, 0.57 ± 0.19 vs 1.16 ± 0.15 (p < 0.05). Uremic rats fed HF diet showed more severe vascular calcification (VC) than rats fed NF diet (aortic Ca = 6.3 ± 1.4 vs 1.4 ± 0.1 mg/g tissue, p < 0.001). In conclusion, energy-rich diets increased plasma levels of FGF23, a known risk factor of cardiovascular morbidity and mortality. Even though FGF23 has major phosphaturic actions, feeding HF diets resulted in P retention, likely secondary to decreased renal klotho, and aggravated uremic VC | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature.com | es_ES |
dc.rights | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.source | Scientific Reports 6:36881 (2016) | es_ES |
dc.subject | Rats | es_ES |
dc.subject | Renal function | es_ES |
dc.subject | energy-rich diets | es_ES |
dc.title | Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/srep36881 | es_ES |
dc.relation.projectID | Gobierno de España. PI14/00467-PI14/00638 | es_ES |
dc.relation.projectID | Junta de Andalucía. PI-0272-2014 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |