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dc.contributor.authorRaya, Ana I.
dc.contributor.authorRíos, Rafael
dc.contributor.authorPineda Martos, Carmen María
dc.contributor.authorRodríguez-Ortiz, Maria E.
dc.contributor.authorDíez, Elisa
dc.contributor.authorAlmadén Peña, Yolanda
dc.contributor.authorMuñoz-Castañeda, Juan R.
dc.contributor.authorRodríguez, Mariano
dc.contributor.authorAguilera Tejero, Escolástico
dc.contributor.authorLópez, Ignacio
dc.date.accessioned2018-12-07T11:21:47Z
dc.date.available2018-12-07T11:21:47Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10396/17560
dc.description.abstractRats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function (Experiment 3, n = 12) were also fed NF or HF diets with high P (HP). Additionally, uremic (5/6Nx) rats (n = 16) were fed HP diets with NF or HF. Feeding the HF diets resulted in significant elevation of plasma FGF23 vs rats fed NF diets: Experiment 1, 593 ± 126 vs 157 ± 28 pg/ ml (p < 0.01); Experiment 2, 538 ± 105 vs 250 ± 18 pg/ml (p < 0.05); Experiment 3, 971 ± 118 vs 534 ± 40 pg/ml (p < 0.01). Rats fed HF diets showed P retention and decreased renal klotho (ratio klotho/actin) vs rats fed NF diets: Experiment 1, 0.75 ± 0.06 vs 0.97 ± 0.02 (p < 0.01); Experiment 2, 0.69 ± 0.07 vs 1.12 ± 0.08 (p < 0.01); Experiment 3, 0.57 ± 0.19 vs 1.16 ± 0.15 (p < 0.05). Uremic rats fed HF diet showed more severe vascular calcification (VC) than rats fed NF diet (aortic Ca = 6.3 ± 1.4 vs 1.4 ± 0.1 mg/g tissue, p < 0.001). In conclusion, energy-rich diets increased plasma levels of FGF23, a known risk factor of cardiovascular morbidity and mortality. Even though FGF23 has major phosphaturic actions, feeding HF diets resulted in P retention, likely secondary to decreased renal klotho, and aggravated uremic VCes_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNature.comes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceScientific Reports 6:36881 (2016)es_ES
dc.subjectRatses_ES
dc.subjectRenal functiones_ES
dc.subjectenergy-rich dietses_ES
dc.titleEnergy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/srep36881es_ES
dc.relation.projectIDGobierno de España. PI14/00467-PI14/00638es_ES
dc.relation.projectIDJunta de Andalucía. PI-0272-2014es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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