Mostrar el registro sencillo del ítem

dc.contributor.authorLópez, Ignacio
dc.contributor.authorPineda Martos, Carmen María
dc.contributor.authorMuñoz, Luis
dc.contributor.authorRaya, Ana I.
dc.contributor.authorLópez, Guillermo
dc.contributor.authorAguilera Tejero, Escolástico
dc.date.accessioned2018-12-07T11:29:15Z
dc.date.available2018-12-07T11:29:15Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10396/17561
dc.description.abstractTo document the biochemical and pathologic features of vitamin D intoxication in lynx and to characterize mineral metabolism in healthy lynx, blood samples were obtained from 40 captive lynx that had been receiving excessive (approximately 30 times the recommended dose) vitamin D3 in the diet, and from 29 healthy free ranging lynx. Tissue samples (kidney, stomach, lung, heart and aorta) were collected from 13 captive lynx that died as a result of renal disease and from 3 controls. Vitamin D intoxication resulted in renal failure in most lynx (n = 28), and widespread extraskeletal calcification was most severe in the kidneys and less prominent in cardiovascular tissues. Blood minerals and calciotropic hormones in healthy lynx were similar to values reported in domestic cats except for calcitriol which was higher in healthy lynx. Changes in mineral metabolism after vitamin D intoxication included hypercalcemia (12.0 ± 0.3 mg/dL), hyperphosphatemia (6.3 ± 0.4 mg/dL), increased plasma calcidiol (381.5 ± 28.2 ng/mL) and decreased plasma parathyroid hormone (1.2 ± 0.7 pg/ mL). Hypercalcemia and, particularly, hyperphosphatemia were of lower magnitude that what has been previously reported in the course of vitamin D intoxication in other species. However, extraskeletal calcifications were severe. The data suggest that lynx are sensitive to excessive vitamin D and extreme care should be taken when supplementing this vitamin in captive lynx diets.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourcePLoS ONE 11(5): e0156331 (2016)es_ES
dc.subjectLynxes_ES
dc.subjectHypervitaminosis Des_ES
dc.subjectVitamin D intoxicationes_ES
dc.titleChronic Vitamin D Intoxication in Captive Iberian Lynx (Lynx pardinus)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal. pone.0156331es_ES
dc.relation.projectIDGobierno de España. LIFE06NAT/E/000209es_ES
dc.relation.projectIDJunta de Andalucía. CTS-179es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem