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Subtle chemical modification for enrichment of Fmoc-amino acid at a phospholipid interface
dc.contributor.author | Argudo, Pablo G. | |
dc.contributor.author | Contreras-Montoya, Rafael | |
dc.contributor.author | Álvarez de Cienfuegos, Luis | |
dc.contributor.author | Martín-Romero, M.T. | |
dc.contributor.author | Camacho, Luis | |
dc.contributor.author | Giner-Casares, Juan J. | |
dc.date.accessioned | 2020-12-02T08:50:51Z | |
dc.date.available | 2020-12-02T08:50:51Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://hdl.handle.net/10396/20874 | |
dc.description.abstract | Amino acids including the Fmoc group (9-fluorenylmethyloxycarbonyl) are bioinspired molecules that display intriguing features in self-assembly and biological applications. The influence of a delicate chemical modification between Fmoc-F and Fmoc-Y on the interaction with a phospholipid surface was analyzed. Langmuir monolayers of the 1,2-dimyristoyl-sn-glycero-3-phosphate (DMPA) phospholipid were used to mimic the eukaryotic cell membrane. In situ Brewster angle microscopy and UV-vis reflection spectroscopy provided insights on the effect of the Fmoc-amino acid derivatives on the DMPA phospholipid. The formation of H-bonds between the Fmoc-Y and the DMPA molecules was assessed, demonstrating the crucial role of the hydroxyl group of Fmoc-Y in enhancing the interaction with biosurfaces. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | RSC Advances 9, 37188 (2019) | es_ES |
dc.subject | Amino acids | es_ES |
dc.subject | Fluorenylmethyloxycarbonyl protecting group | es_ES |
dc.subject | Fmoc-F | es_ES |
dc.subject | Fmoc-Y | es_ES |
dc.subject | Chemical modification | es_ES |
dc.subject | DMPA phospholipid | es_ES |
dc.title | Subtle chemical modification for enrichment of Fmoc-amino acid at a phospholipid interface | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c9ra03896e | es_ES |
dc.relation.projectID | Gobierno de España. CTQ2017-83961-R | es_ES |
dc.relation.projectID | Gobierno de España. FIS2017-85954-R | es_ES |
dc.relation.projectID | Gobierno de España. RyC-2014-14956 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |