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dc.contributor.authorVidal, Ángela
dc.contributor.authorRíos, Rafael
dc.contributor.authorPineda, Carmen
dc.contributor.authorLópez, Ignacio
dc.contributor.authorRaya, Ana I.
dc.contributor.authorAguilera Tejero, Escolástico
dc.contributor.authorLópez Rivero, J.L.
dc.date.accessioned2021-02-15T08:05:59Z
dc.date.available2021-02-15T08:05:59Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/21073
dc.description.abstractThe influence of energy restriction (ER) on muscle is controversial, and the mechanisms are not well understood. To study the effect of ER on skeletal muscle phenotype and the influence of vitamin D, rats (n = 34) were fed a control diet or an ER diet. Muscle mass, muscle somatic index (MSI), fiber-type composition, fiber size, and metabolic activity were studied in tibialis cranialis (TC) and soleus (SOL) muscles. Plasma vitamin D metabolites and renal expression of enzymes involved in vitamin D metabolism were measured. In the ER group, muscle weight was unchanged in TC and decreased by 12% in SOL, but MSI increased in both muscles (p < 0.0001) by 55% and 36%, respectively. Histomorphometric studies showed 14% increase in the percentage of type IIA fibers and 13% reduction in type IIX fibers in TC of ER rats. Decreased size of type I fibers and reduced oxidative activity was identified in SOL of ER rats. An increase in plasma 1,25(OH)2-vitamin D (169.7 ± 6.8 vs. 85.4 ± 11.5 pg/mL, p < 0.0001) with kidney up-regulation of CYP27b1 and down-regulation of CYP24a1 was observed in ER rats. Plasma vitamin D correlated with MSI in both muscles (p < 0.001), with the percentages of type IIA and type IIX fibers in TC and with the oxidative profile in SOL. In conclusion, ER preserves skeletal muscle mass, improves contractile phenotype in phasic muscles (TC), and reduces energy expenditure in antigravity muscles (SOL). These beneficial effects are closely related to the increases in vitamin D secondary to ER.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceNutrients 13(2), 607 (2021)es_ES
dc.subjectEnergy restrictiones_ES
dc.subjectMusclees_ES
dc.subjectVitamin Des_ES
dc.subjectRates_ES
dc.titleIncreased 1,25(OH)2-Vitamin D Concentrations after Energy Restriction Are Associated with Changes in Skeletal Muscle Phenotypees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/nu13020607es_ES
dc.relation.projectIDInstituto de Salud Carlos III. PI17/00169es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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