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dc.contributor.authorMolina Luque, Rafael
dc.contributor.authorUlloa, Natalia
dc.contributor.authorRomero Saldaña, Manuel
dc.contributor.authorZilic, Martin
dc.contributor.authorGleisner, Andrea
dc.contributor.authorLanuza, Fabián
dc.contributor.authorMolina Recio, Guillermo
dc.date.accessioned2021-06-11T11:02:22Z
dc.date.available2021-06-11T11:02:22Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10396/21416
dc.description.abstractThe increasing prevalence of obesity in children has raised the incidence of Metabolic Syndrome (MetS) in this age group. Given the short- and long-term health impact of MetS, it is essential to prevent its onset by detecting its main triggers. Besides, genetic factors play an essential role in influencing which individuals within a population are most likely to develop obesity in response to a particular environment. In this regard, a common variation in the FTO gene is reproducibly associated with BMI and obesity from childhood and the genetic load has been linked to several cardiovascular risk factors, highlighting the FTO single nucleotide polymorphism (SNP) rs9939609. Therefore, this study aimed to establish the relationship between the FTO SNP rs9939609 and MetS. Methods: A cross-sectional study was carried out on 220 children from the Biobío region (Chile). MetS diagnosis was established through the modified Cook criteria, using prevalence ratios, COR curves, and linear regressions to determine its association with MetS and its components. Results: The prevalence of MetS was significantly increased among carriers of the risk allele (A): TT, 20.2%; TA, 25.4%; AA, 44.7% (p = 0.006). Also, the presence of A was associated with altered MetS-related variables. Conclusions: The FTO SNP rs9939609 was associated with a raised prevalence of MetS among A allele carriers, and was higher in the homozygous genotype (AA).es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceNutrients 13(6), 2014 (2021)es_ES
dc.subjectFTO genees_ES
dc.subjectMetabolic syndromees_ES
dc.subjectChildrenes_ES
dc.titleAssociation between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Childrenes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/nu13062014es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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