• A Pilot Study on the Feasibility of Developing and Implementing a Mobile App for the Acquisition of Clinical Knowledge and Competencies by Medical Students Transitioning from Preclinical to Clinical Years 

      Prados-Carmona, Álvaro; Fuentes-Jiménez, Francisco J.; Román de los Reyes, Rafael; García-Ríos, Antonio; Rioja-Bravo, Jesús; Herruzo Gómez, Ezequiel; Pérez-Martinez, Pablo; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2022)
      Due to the COVID-19 pandemic and the consequent restrictions, universities have had to adapt their curricula substantially to new schemes in which remote learning is of the essence. In this study, we assess the feasibility ...
    • A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study 

      Villasanta-González, Alejandro; Alcalá Díaz, Juan Francisco; Vals-Delgado, Cristina; Arenas, Antonio Pablo; Cardelo, Magdalena P.; Romero-Cabrera, Juan Luis; Rodríguez-Cantalejo, Fernando; Delgado-Lista, Javier; Malagón, María M.; Pérez-Martínez, Pablo; Schulze, Matthias B.; Camargo García, A.; López-Miranda, José (Springer, 2021)
      Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We ...
    • A polymorphism exon 1 variant at the locus of the scavenger receptor class B type I (SCARB1) gene is associated with differences in insulin sensitivity in healthy people during the consumption of an olive oil-rich diet 

      Pérez-Martínez, Pablo; Pérez-Jiménez, Francisco; Bellido, Cecilia; Ordovas, José M.; Moreno, Juan Antonio; Marín, Carmen; Gómez, Purificación; Delgado-Lista, Javier; Fuentes, Francisco; López Miranda, José (Oxford Academic, 2005)
      Scavenger receptor class B type I (SCARB1) was described as the first high-density lipoprotein receptor. Increasing evidence indicates that SCARB1 plays additional roles particularly in type 2 diabetes mellitus. Our aim ...
    • A single nucleotide polymorphism of the apolipoprotein A-V gene -1131T>C modulates postprandial lipoprotein metabolism 

      Moreno, Rafael; Pérez-Jiménez, Francisco; Marín, Carmen; Moreno, Juan Antonio; Gómez, Purificación; Bellido, Cecilia; Pérez Martínez, Pablo; Jiménez Gómez, Yolanda; José Fuentes, Francisco; López Miranda, José (Elsevier, 2006)
      The Apolipoprotein A–V (apoA–V) gene promoter polymorphism −1131T > C modulates triacylglycerol (TG) concentrations. We evaluate whether this polymorphism could be involved in the interindividual variability observed during ...
    • Aceite de oliva y prevención cardiovascular: más que una grasa 

      Delgado Lista, José; López Segura, Fernando; Pérez-Martínez, Pablo; Pérez-Jiménez, Francisco; López-Miranda, José (Instituto de Estudio Jiennenses, 2007)
    • Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People 

      Muñoz-Pérez, Diana María; González-Correa, Clara Helena; Astudillo-Muñoz, Elcy Yaned; Porras-Hurtado, Gloria Liliana; Sánchez-Giraldo, Maite; López-Miranda, José; Camargo García, A.; Rangel Zúñiga, Oriol Alberto (MDPI, 2021)
      Obesity is one of the major health problems worldwide. Following healthy dietary patterns can be difficult in some countries due to the lack of availability of certain foods; thus, alternative foods are needed. Our aim was ...
    • An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study 

      Vals-Delgado, Cristina; Alcalá-Diaz, Juan F.; Molina-Abril, Helena; Roncero-Ramos, Irene; Caspers, Martien P.M.; Schuren, Frank H.J.; Broek, Tim J. Van den; Luque, Raúl M.; Pérez-Martínez, Pablo; Katsiki, Niki; Delgado-Lista, Javier; Ordovas, José M.; Ommene, Ben van; Camargo García, A.; López-Miranda, José (Elsevier, 2021)
      Introduction. A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of ...
    • Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19 

      Roy Vallejo, Emilia; Sánchez Purificación, Aquilino; Torres‑Peña, J.D.; Sánchez Moreno, Beatriz; Arnalich-Fernández, Francisco; García Blanco, María José; López-Miranda, José; Romero-Cabrera, Juan Luis; Herrero Gil, Carmen Rosario; Bascunana, José; Rubio-Rivas, Manuel; Pintos Otero, Sara; Martínez Sempere, Verónica; Ballano Rodríguez-Solís, Jesús; Gil Sánchez, Ricardo; Luque del Pino, Jairo; González Noya, Amara; Navas-Alcántara, María Sierra; Cortés Rodríguez, Begoña; Alcalá, José Nicolás; Suárez-Lombraña, Ana; Soler, Jorge Andrés; Gómez-Huelgas, Ricardo; Casas-Rojo, José Manuel; Millán Núñez-Cortés, Jesús; SEMI‐COVID‐19 Network (MDPI, 2021)
      Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter ...
    • Apolipoprotein E gene promoter -219G->T polymorphism increases LDL-cholesterol concentrations and susceptibility to oxidation in response to a diet rich in saturated fat. 

      Moreno, Juan Antonio; Pérez-Jiménez, Francisco; Marín, Carmen; Gómez, Purificación; Pérez-Martínez, Pablo; Moreno, Rafael; Bellido, Cecilia; Fuentes, Francisco; López Miranda, José (Elsevier, 2004)
      Background The apolipoprotein E (APOE) gene promoter polymorphism (−219G→T) has been associated with increased risk of myocardial infarction, premature coronary artery disease, and decreased plasma apolipoprotein E ...
    • Association between Diet Quality and Risk of Type 2 Diabetes Mellitus in Patients with Coronary Heart Disease: Findings from the CORDIOPREV Study 

      Rivas García, Lorenzo; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Rangel-Zuñiga, Oriol Alberto; López-Moreno, Alejandro; Malagón, María M.; Katsiki, Niki; Pérez Martínez, Pablo; López Miranda, José; Delgado-Lista, Javier (MDPI, 2024)
      The incidence of type 2 diabetes mellitus (T2DM) is growing in Western countries. Nutritional interventions that promote high-quality dietary patterns could help reverse this trend. We aimed to evaluate whether changes in ...
    • Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial 

      Roncero-Ramos, Irene; Gutiérrez Mariscal, Francisco Miguel; Gómez Delgado, Francisco; Villasanta-González, Alejandro; Torres‑Peña, J.D.; Cruz‐Ares, Silvia de la; Rangel Zúñiga, Oriol Alberto; Luque, Raúl M.; Ordovas, José M.; Delgado-Lista, Javier; Pérez-Martínez, Pablo; Camargo García, A.; Alcalá Díaz, Juan Francisco; López-Miranda, José (Elsevier, 2021)
      In order to assess whether previous hepatic IR (Hepatic-IR fasting) and beta-cell functionality could modulate type 2 diabetes remission and the need for starting glucose- lowering treatment, newly-diagnosed type 2 diabetes ...
    • Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study 

      Alcalá Díaz, Juan Francisco; Limia-Pérez, Laura; Gómez-Huelgas, Ricardo; Martín-Escalante, María D.; Cortés Rodríguez, Begoña; Zambrana-García, José L.; Entrenas-Castillo, Marta; Pérez-Caballero, Ana I.; López-Carmona, María D.; García-Alegría, Javier; Lozano Rodríguez-Mancheño, Aquiles; Arenas-de Larriva, María del Sol; Pérez-Belmonte, Luis M.; Jungreis, Irwin; Bouillon, Roger; Quesada Gómez, José Manuel; López-Miranda, José (MDPI, 2021)
      Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients. Objective: To compare the administration or not of oral calcifediol on mortality risk of patients hospitalized because of COVID-19. ...
    • Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes 

      Paniagua, Juan Antonio; López Miranda, José; Escribano, A.; Berral de la Rosa, Francisco José; Marín, Carmen; Bravo, D.; Paz-Rojas, Elier; Gómez, Purificación; Barcos, Montserrat; Moreno, Juan Antonio; Pérez-Jiménez, Francisco (American Diabetes Association, 2002)
    • Ceruloplasmin and Coronary Heart Disease-A Systematic Review 

      Arenas de Larriva, Antonio P.; Limia-Pérez, Laura; Alcalá Díaz, Juan Francisco; Alonso, Álvaro; López-Miranda, José; Delgado-Lista, Javier (MDPI, 2020)
      Several studies indicate that oxidative stress might play a central role in the initiation and maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a passive marker of inflammation or ...
    • Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study 

      Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)
      Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...
    • Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer 

      Jiménez-Vacas, J.M.; Gómez Gómez, Enrique; Montero-Hidalgo, Antonio J.; Herrero-Aguayo, V.; L-López, Fernando; Sánchez-Sánchez, Rafael; Guler, Ipek; Blanca, Ana; Méndez-Vidal, María José; Carrasco, Julia; López-Miranda, José; Requena-Tapia, M.J.; Castaño, Justo P.; Gahete Ortiz, Manuel D.; Luque, Raúl M. (MDPI, 2019)
      Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/agg ...
    • Coenzyme Q10 and Cardiovascular Diseases 

      Gutiérrez Mariscal, Francisco Miguel; Cruz‐Ares, Silvia de la; Torres‑Peña, J.D.; Alcalá-Diaz, Juan F.; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2021)
      Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell ...
    • Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases 

      Gutiérrez Mariscal, Francisco Miguel; Arenas de Larriva, Antonio P.; Limia-Pérez, Laura; Romero-Cabrera, Juan Luis; Yubero-Serrano, Elena M.; López-Miranda, José (MDPI, 2020)
      Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the ...
    • Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study 

      Cardelo, Magdalena P.; Alcalá Díaz, Juan Francisco; Gutiérrez Mariscal, Francisco Miguel; López Moreno, Javier; Villasanta-González, Alejandro; Arenas de Larriva, Antonio P.; Cruz Ares, Silvia de la; Delgado-Lista, Javier; Rodríguez-Cantalejo, Fernando; Luque, Raúl M.; Ordovás, José María; Pérez Martínez, Pablo; Camargo García, A.; López Miranda, José (Wiley, 2021)
      Scope: Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet. Methods: ...
    • Diagnostic Precision of Anthropometric Variables for the Detection of Hypertension in Children and Adolescents 

      Vaquero Álvarez, Manuel; Molina Luque, Rafael; Fonseca del Pozo, Francisco Javier; Molina Recio, Guillermo; López-Miranda, José; Romero Saldaña, Manuel (MDPI, 2020)
      Introduction: High blood pressure (HBP) is a health problem the prevalence of which has increased in young populations. Overweight and obesity in early ages have been directly related to its development. Due to the impact ...