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Polydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometry

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Author
Véjar-Vivar, C.
Millán-Santiago, Jaime
Mardones, C.
Lucena, Rafael
Cárdenas, Soledad
Publisher
Elsevier
Date
2022
Subject
Illicit drugs
Oral fluid
Polydopamine modified hypodermic needles
Electrospray emitter
Ambient ionization mass spectrometry
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Abstract
In this article, polydopamine inner wall-coated hypodermic needles (PDA-HNs) are evaluated as both microextraction devices and electrospray ionization (ESI) emitters for determining selected illicit drugs (methamphetamine, cocaine, and methadone) in oral fluid samples. The PDA film, located in the inner wall of the needle, allows the extraction of the analytes at alkaline pH, where their hydrophobic character is promoted. The extracted analytes are finally eluted in a methanol/formic acid mixture that also acts as ESI solution. For this purpose, a dedicated interface based on the connection of a PEEK tube with the needle hub is proposed. This assembly allows delivering the ESI solution by the infusion syringe pump of the mass spectrometer, providing an efficient ESI on the tip of the needle. The double use of the PDA-HNs as microextraction devices and ESI emitters permits the determination of the target analytes with limits of detection and precision (expressed as relative standard deviation) values better than 2.4 μg/L and 17.6%, respectively. The accuracy was evaluated by analyzing independent spiked oral fluid samples, obtaining good results.
Description
Embargado hasta 01/11/2024
URI
http://hdl.handle.net/10396/23304
Fuente
Talanta 249, 123693 (2022)
Versión del Editor
https://doi.org/10.1016/j.talanta.2022.123693
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