Show simple item record

dc.contributor.authorVéjar-Vivar, C.
dc.contributor.authorMillán-Santiago, Jaime
dc.contributor.authorMardones, C.
dc.contributor.authorLucena, Rafael
dc.contributor.authorCárdenas, Soledad
dc.date.accessioned2022-06-23T10:18:15Z
dc.date.available2022-06-23T10:18:15Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/10396/23304
dc.descriptionEmbargado hasta 01/11/2024es_ES
dc.description.abstractIn this article, polydopamine inner wall-coated hypodermic needles (PDA-HNs) are evaluated as both microextraction devices and electrospray ionization (ESI) emitters for determining selected illicit drugs (methamphetamine, cocaine, and methadone) in oral fluid samples. The PDA film, located in the inner wall of the needle, allows the extraction of the analytes at alkaline pH, where their hydrophobic character is promoted. The extracted analytes are finally eluted in a methanol/formic acid mixture that also acts as ESI solution. For this purpose, a dedicated interface based on the connection of a PEEK tube with the needle hub is proposed. This assembly allows delivering the ESI solution by the infusion syringe pump of the mass spectrometer, providing an efficient ESI on the tip of the needle. The double use of the PDA-HNs as microextraction devices and ESI emitters permits the determination of the target analytes with limits of detection and precision (expressed as relative standard deviation) values better than 2.4 μg/L and 17.6%, respectively. The accuracy was evaluated by analyzing independent spiked oral fluid samples, obtaining good results.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceTalanta 249, 123693 (2022)es_ES
dc.subjectIllicit drugses_ES
dc.subjectOral fluides_ES
dc.subjectPolydopamine modified hypodermic needleses_ES
dc.subjectElectrospray emitteres_ES
dc.subjectAmbient ionization mass spectrometryes_ES
dc.titlePolydopamine inner wall-coated hypodermic needle as microextraction device and electrospray emitter for the direct analysis of illicit drugs in oral fluid by ambient mass spectrometryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.talanta.2022.123693es_ES
dc.relation.projectIDGobierno de España. PID2020-112862RB-I00es_ES
dc.relation.projectIDGobierno de España. MCIN/AEI/10.13039/501100011033es_ES
dc.relation.projectIDGobierno de España. FPU19/01488es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record