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A Continuous flow approach for the desulfurative bromination of sulfides
dc.contributor.author | Pineda, Antonio | |
dc.contributor.author | Carr, James | |
dc.contributor.author | Rodríguez-Padrón, Daily | |
dc.contributor.author | Lázaro, Noelia | |
dc.contributor.author | Fox, Karen | |
dc.contributor.author | González-Arellano, Camino | |
dc.contributor.author | Gillick-Healy, Malachi W. | |
dc.contributor.author | Kelly, Brian G. | |
dc.contributor.author | Adamo, Mauro F. A. | |
dc.contributor.author | Luque, Rafael | |
dc.date.accessioned | 2024-03-18T13:22:00Z | |
dc.date.available | 2024-03-18T13:22:00Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | http://hdl.handle.net/10396/27701 | |
dc.description.abstract | The preparation of alkyl bromides is a pivotal transformation in organic chemistry. The wide range of applications that bromides have as building blocks render this class of compounds a privileged motif widely used in the manufacture of active pharmaceutical ingredients. Traditionally prepared from the deoxygenation of alcohols, alkyl bromides have been recently obtained from sulfides in high yields, a transformation we have named desulfurative bromination. In order to improve the efficiency of this transformation, we report herein the investigation and optimisation of a continuous flow strategy. The influence of the flow rate; role of the brominating agent; and substrate scope have been studied delivering an in-flow protocol to access multigram quantities of these valuable intermediates | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | Antonio Pineda, James Carr, Daily Rodríguez-Padrón, Noelia Lázaro Ronco, Karen Fox, Camino Gonzalez-Arellano, Malachi W. Gillick-Healy, Brian G. Kelly, Mauro F.A. Adamo, Rafael Luque, A continuous flow approach for the desulfurative bromination of sulfides, Sustainable Chemistry and Pharmacy, Volume 38, 2024. | es_ES |
dc.subject | Nucleophilic Substitution | es_ES |
dc.subject | Synthetic methods | es_ES |
dc.subject | Bromination | es_ES |
dc.subject | Continuous flow | es_ES |
dc.title | A Continuous flow approach for the desulfurative bromination of sulfides | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.scp.2024.101490 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/823939 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |