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Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study
dc.contributor.author | Cardelo, Magdalena P. | |
dc.contributor.author | Alcalá Díaz, Juan Francisco | |
dc.contributor.author | Gutiérrez Mariscal, Francisco Miguel | |
dc.contributor.author | López Moreno, Javier | |
dc.contributor.author | Villasanta-González, Alejandro | |
dc.contributor.author | Arenas de Larriva, Antonio P. | |
dc.contributor.author | Cruz Ares, Silvia de la | |
dc.contributor.author | Delgado-Lista, Javier | |
dc.contributor.author | Rodríguez-Cantalejo, Fernando | |
dc.contributor.author | Luque, Raúl M. | |
dc.contributor.author | Ordovás, José María | |
dc.contributor.author | Pérez Martínez, Pablo | |
dc.contributor.author | Camargo García, A. | |
dc.contributor.author | López Miranda, José | |
dc.date.accessioned | 2024-05-21T11:34:43Z | |
dc.date.available | 2024-05-21T11:34:43Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/10396/28357 | |
dc.description.abstract | Scope: Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet. Methods: One hundred eighty-three newly diagnosed T2DM patients within the CORDIOPREV study are randomized to consume the Med or a LF diet. BCAA plasma levels (isoleucine, leucine, and valine) are measured at fasting and after 120 min of an oral glucose tolerance test (OGTT) at the baseline of the study and after 5 years of the dietary intervention. Results: Isoleucine, leucine, and valine plasma levels after 120 min of an OGTT in the Med diet (N = 80) are associated by COX analysis with T2DM remission: HR per SD (95% CI): 0.53 (0.37–0.77), 0.75 (0.52–1.08), and 0.61 (0.45–0.82), respectively; no association is found in patients who consumed a LF diet (N = 103). BCAA plasma levels combined in a score show a HR of 3.33 (1.55–7.19) of T2DM remission for patients with a high score values in the Med diet, while in those with a LF diet, no association is found. Conclusión: The study suggests that BCAA measurements potentially be used as a tool to select the most suitable diet to induce T2DM remission by nutritional strategies. | es_ES |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.source | M. P. Cardelo, J. F. Alcala-Diaz, F. M. Gutierrez-Mariscal, J. Lopez-Moreno, A. Villasanta-Gonzalez, A. P. Arenas-deLarriva, S. de la Cruz-Ares, J. Delgado-Lista, F. Rodriguez-Cantalejo, R. M. Luque, J. M. Ordovas, P. Perez-Martinez, A. Camargo, J. Lopez-Miranda, Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study. Mol. Nutr. Food Res. 2022, 66, 2100652. | es_ES |
dc.subject | Branched chain amino acids | es_ES |
dc.subject | CORDIOPREV study | es_ES |
dc.subject | Mediterranean diet | es_ES |
dc.subject | Type 2 diabetes remission | es_ES |
dc.title | Diabetes Remission Is Modulated by Branched Chain Amino Acids According to the Diet Consumed: From the CORDIOPREV Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/mnfr.202100652 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/AGL2012/39615 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/PIE14/00005 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/PIE14/00031 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/AGL2015-67896-P | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/CP14/00114 | es_ES |
dc.relation.projectID | Gobierno de España.ISCIII/PI19/00299 | es_ES |
dc.relation.projectID | Gobierno de España.ISCIII/DTS19/00007 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/PI13/00023 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/PI16/01777 | es_ES |
dc.relation.projectID | Junta de Andalucía.CVI-7450 | es_ES |
dc.relation.projectID | Gobierno de España.MINECO/CP14/00114 | es_ES |
dc.relation.projectID | Gobierno de España.ISCIII/CPII19/00007 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |