Listar DBCFI-Artículos, capítulos... por fecha de publicación

Mostrando ítems 61-80 de 188

    • La ecoinnovación en el sector agroalimentario: ¿qué puede aportar el Campus? 

      Castaño, Justo P.; Domínguez García-Barquero, Ricardo (Campus de Excelencia Internacional Agroalimentario, 2012)

    • The Somatostatin Analogue Octreotide Inhibits Growth of Small Intestine Neuroendocrine Tumour Cells 

      Li, Su-Chen; Martijn, Cécile; Cui, Tao; Essaghir, Ahmed; Luque, Raúl M.; Demoulin, Jean-Baptiste; Castaño, Justo P.; Öberg, Kjell; Giandomenico, Valeria (Public Library Of Science (PLOS), 2012)
      Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms ...

    • The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes 

      Rodríguez, A; Gómez-Ambrosi, Javier; Catalán, Victoria; Rotellar, Fernando; Valentí, Víctor; Silva, Camilo; Mugueta, C.; Pulido, Marina R.; Vázquez, R.; Salvador, Javier; Malagón, María M.; Colina, I.; Frühbeck, Gema (SpringerLink, 2012)
      Aims/hypothesis Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...

    • The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity 

      Moreno-Navarrete, José María; Catalán, Victoria; Whyte, Lauren; Díaz-Arteaga, Adenis; Vázquez-Martínez, Rafael; Rotellar, Fernando; Guzmán-Ruiz, Rocío; Gómez-Ambrosi, Javier; Pulido, Marina R.; Russell, Wendy R.; Imbernón, Mónica; Ross, Ruth A.; Malagón, María M.; Diéguez, Carlos; Fernández-Real, José Manuel; Frühbeck, Gema; Nogueiras, Rubén (American Diabetes Asociation, 2012)
      GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ...

    • Método de obtención de datos útiles para predecir la respuesta al tratamiento de la Hepatitis C 

      Peña Martínez, José; Torre-Cisneros, Julián de la; Rivero Román, Antonio; González Fernández, Rafael A.; Manzanares Martín, Bárbara; Rivero Juárez, Antonio; Camacho Espejo, Ángela (Oficina de Transferencia de Resultados de la Investigación, 2013)
      La presente invención proporciona un método de obtención de datos útiles para predecir cual será la respuesta de un paciente al tratamiento de la hepatitis C, específicamente al tratamiento con interferón pegilado y ...

    • The Fusarium oxysporum gnt2, Encoding a Putative NAcetylglucosamine Transferase, Is Involved in Cell Wall Architecture and Virulence 

      López Fernández, Loida; Ruiz Roldán, Carmen; Pareja Jaime, Y.; Prieto, A.; Khraiwesh, Husam M.; González Roncero, M. Isabel (Public Library of Science, 2013)
      With the aim to decipher the molecular dialogue and cross talk between Fusarium oxysporum f.sp. lycopersci and its host during infection and to understand the molecular bases that govern fungal pathogenicity, we analysed ...

    • Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions 

      Chanclón García, Belén; Luque, Raúl M.; Córdoba-Chacón, José; Gahete Ortiz, Manuel D.; Pozo-Salas, Ana I.; Castaño, Justo P.; Gracia-Navarro, F.; Martínez-Fuentes, Antonio J. (Public Library Of Science (PLOS), 2013)
      Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)] are expressed in a wide variety of tissues, including the pancreas, where they exert different ...

    • Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue 

      Pulido, Marina R.; Rabanal Ruiz, Yoana; Almabouada, Farid; Díaz-Ruiz, Alberto; Burrel, María A; Vázquez, María J.; Castaño, Justo P.; Kineman, Rhonda D.; Luque, Raúl M.; Diéguez, Carlos; Vázquez-Martínez, Rafael; Malagón, María M. (Society for Endocrinology, 2013)
      There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...

    • The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy 

      Lozoya, Teresa; Domínguez, Francisco; Romero-Ruiz, Antonio; Steffani, Liliana; Martínez, Sebastián; Monterde, Mercedes; Ferri, Blanca; Núñez, María José; Romero- Espino, Ainoha; Zamora, Omar; Gurrea, Marta; Sangiao-Alvarellos, Susana; Vega, Olivia; Simón, Carlos; Pellicer, Antonio; Tena-Sempere, Manuel (PLOS, 2014)
      Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role ...

    • Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma 

      Guil-Luna, Silvia; Stenvang, Jan; Brünner, Nils; De Andrés, Francisco Javier; Sánchez Céspedes, Raquel; Millán, Yolanda; Martín de las Mulas González-Albo, Juana (BioMed Central, 2014)
      Background: Progesterone receptors play a key role in the development of canine mammary tumours, and recent research has focussed on their possible value as therapeutic targets using antiprogestins. Cloning and sequencing of ...

    • CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals 

      Pera Rojas, Alejandra; Campos Fernández, Carmen; Sánchez-Correa, Beatriz; Tarazona, Raquel; Larbi, Anis; Solana Lara, Rafael; Alonso, Corona (Public Library of Science, 2014)
      Cytomegalovirus (CMV) latent infection has a deleterious effect on the efficacy of influenza vaccination in the elderly, suggesting that CMV restricts immunological diversity impairing the immune system functionality in ...

    • Los estudios veterinarios de D. Juan Darbón Díaz, el "médico de Platero" 

      Escribano, Begoña M.; Ul Ain, Qurrat; Padilla Díaz de la Serna, Santiago; Carrasco Otero, Librado; Marín Garrido, Antonio (RACVAO, 2014)
      Con este artículo queremos dar a conocer la vida académica, y el contexto en que esta se desarrolló, del Veterinario D.Juan Darbón Díaz, uno de los personajes que aparecen en la novela “Platero y yo”, obra en la que la ...

    • In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features 

      Ibáñez-Costa, Alejandro; Gahete Ortiz, Manuel D.; Rivero-Cortés, Esther; Rincón-Fernández, David; Nelson, Richard; Beltrán, Manuel; Riva, Andrés de la; Japón, Miguel A.; Venegas-Moreno, Eva; García-Arnés, Juan A.; Soto-Moreno, Alfonso; Morgan, Jennifer; Tsomaia, Natia; Culler, Michael D.; Diéguez, Carlos; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2015)
      Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin ...

    • Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells 

      García, Víctor; Lara Chica, M. Isabel; Cantarero, Irene; Sterner, Olov; Muñoz, Eduardo; Calzado Canale, Marco Antonio (Impact Journals, 2015)
      Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and ...

    • Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly 

      Martín, Juan Francisco; Muñoz-Bravo, José L.; Ibáñez-Costa, Alejandro; Fernández-Maza, Laura; Balcerzyk, Marcin; Leal Campanario, Rocío; Luque, Raúl M.; Castaño, Justo P.; Venegas-Moreno, Eva; Soto-Moreno, Alfonso; Leal-Cerro, Alfonso; Cano, David A. (Nature Research, 2015)
      Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by pituitary adenomas. Elevated GH and IGF-I levels ...

    • Los Murciélagos del complejo Hundidero-Gato 

      Boyero, Juan R.; Tejedor Huerta, Olvido (RACVAO, 2016)

    • Olive Oil and the Hallmarks of Aging 

      Fernández del Río, Lucía; Gutiérrez-Casado, Elena; Varela-López, Alfonso; Villalba, José Manuel (MDPI, 2016)
      Aging is a multifactorial and tissue-specific process involving diverse alterations regardedas the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, ...

    • Mejora de bienestar animal asociada a una alimentación basada en nuevos piensos y forrajes más seguros y digestibles dentro del “Proyecto Ánfora”: presentación de los primeros resultados 

      Requena, F.; Escribano, Begoña M.; Requena, F.D.; Montes, F.; Hernández, M.; Serrano, A.; Cardoso, F.; Agüera, Estrella I. (RACVAO, 2016)

    • Uso de mandos interactivos de respuesta como base para la mejora de la docencia en los Grados impartidos en la Facultad de Ciencias 

      Pérez-Vicente, C.; Siles López, José Ángel; Ruiz Roldán, Carmen; Martínez-Fuentes, Antonio J.; García-Ortiz, M.V.; Martín-Romero, M.T.; Bárcena Ruiz, José Antonio; Padilla Peña, Carmen Alicia; Márquez Espinosa, Ramiro; Vázquez Martínez, Rafael; Díaz Soriano, Antonio Manuel; Marinas, Alberto; Delgado Marzo, Juan Manuel; López Toledano, Azahara; Pérez-Morales, M.; Miguel, Gustavo de (UCOPress, 2017)
      La implantación de los nuevos Grados dentro del EEES supone un nuevo enfoque metodológico, pero sobre todo evaluador. El profesor debe esforzarse en ser capaz de valorar no sólo el nivel de conocimientos del alumnado sobre ...

    • Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue 

      Novelle, Marta G.; Vázquez, María J.; Peinado, Juan R.; Martinello, Kátia D.; López, Miguel; Luckman, Simon M.; Tena-Sempere, Manuel; Malagón, María M.; Nogueiras, Rubén; Diéguez, Carlos (Nature Research, 2017)
      During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ...