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Mostrando ítems 181-188 de 188
Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review
(MDPI, 2024)
Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and ...
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice
(Springer, 2022)
Cytochrome b5 reductase 3 (CYB5R3) overexpression activates respiratory metabolism and exerts prolongevity effects in transgenic mice, mimicking some of the salutary effects of calorie restriction. The aim of our study was ...
An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study
(Elsevier, 2021)
Introduction. A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of ...
Splicing Machinery Is Impaired in Oral Squamous Cell Carcinomas and Linked to Key Pathophysiological Features
(MDPI, 2024)
Alternative splicing dysregulation is an emerging cancer hallmark, potentially serving as a source of novel diagnostic, prognostic, or therapeutic tools. Inhibitors of the activity of the splicing machinery can exert ...
Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy
(MDPI, 2020)
Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the ...
Toll-Like Receptors in Acute Kidney Injury
(MDPI, 2021)
Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is ...
Intravascular hemolysis triggers NAFLD characterized by a deregulation of lipid metabolism and lipophagy blockade
(Wiley, 2023)
Intravascular hemolysis is a common feature of different clinical entities, including sickle cell disease and malaria. Chronic hemolytic disorders are associated with hepatic damage; however, it is unknown whether heme ...
Changes in quantity plant‑based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study
(Springer, 2023)
Purpose: Diabetes remission is a phenomenon described in the context of drastic weight loss due to bariatric surgery or low-calorie diets. Evidence suggests that increasing the intake of plant protein could reduce the risk ...