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Hip Osteoarthritis in Dogs: A Randomized Study Using Mesenchymal Stem Cells from Adipose Tissue and Plasma Rich in Growth Factors

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Author
Cuervo, Belén
Rubio, Mónica
Sopena, Joaquín
Domínguez Pérez, Juan Manuel
Vilar, José
Morales, Manuel
Cugat, Ramón
Carrillo, José María
Publisher
MDPI
Date
2014
Subject
Adipose derived mesenchymal stem cells
Plasma rich in growth factors
Osteoarthritis
Dogs
Hip
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Abstract
Purpose: The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group. Thirty-nine dogs with symptomatic hip OA were assigned to one of the two groups, to receive aMSCs or PRGF. The primary outcome measures were pain and function subscales, including radiologic assessment, functional limitation and joint mobility. The secondary outcome measures were owners’ satisfaction questionnaire, rescue analgesic requirement and overall safety. Data was collected at baseline, then, 1, 3 and 6 months post-treatment. Results: OA degree did not vary within groups. Functional limitation, range of motion (ROM), owner’s and veterinary investigator visual analogue scale (VAS), and patient’s quality of life improved from the first month up to six months. The aMSCs group obtained better results at 6 months. There were no adverse effects during the study. Our findings show that aMSCs and PRGF are safe and effective in the functional analysis at 1, 3 and 6 months; provide a significant improvement, reducing dog’s pain, and improving physical function. With respect to basal levels for every parameter in patients with hip OA, aMSCs showed better results at 6 months.
URI
http://hdl.handle.net/10396/15394
Fuente
International Journal of Molecular Sciences 15(8), 13437-13460 (2014)
Versión del Editor
http://dx.doi.org/10.3390/ijms150813437
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