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dc.contributor.authorCuervo, Belén
dc.contributor.authorRubio, Mónica
dc.contributor.authorSopena, Joaquín
dc.contributor.authorDomínguez Pérez, Juan Manuel
dc.contributor.authorVilar, José
dc.contributor.authorMorales, Manuel
dc.contributor.authorCugat, Ramón
dc.contributor.authorCarrillo, José María
dc.date.accessioned2017-11-09T11:51:57Z
dc.date.available2017-11-09T11:51:57Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10396/15394
dc.description.abstractPurpose: The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group. Thirty-nine dogs with symptomatic hip OA were assigned to one of the two groups, to receive aMSCs or PRGF. The primary outcome measures were pain and function subscales, including radiologic assessment, functional limitation and joint mobility. The secondary outcome measures were owners’ satisfaction questionnaire, rescue analgesic requirement and overall safety. Data was collected at baseline, then, 1, 3 and 6 months post-treatment. Results: OA degree did not vary within groups. Functional limitation, range of motion (ROM), owner’s and veterinary investigator visual analogue scale (VAS), and patient’s quality of life improved from the first month up to six months. The aMSCs group obtained better results at 6 months. There were no adverse effects during the study. Our findings show that aMSCs and PRGF are safe and effective in the functional analysis at 1, 3 and 6 months; provide a significant improvement, reducing dog’s pain, and improving physical function. With respect to basal levels for every parameter in patients with hip OA, aMSCs showed better results at 6 months.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es_ES
dc.sourceInternational Journal of Molecular Sciences 15(8), 13437-13460 (2014)es_ES
dc.subjectAdipose derived mesenchymal stem cellses_ES
dc.subjectPlasma rich in growth factorses_ES
dc.subjectOsteoarthritises_ES
dc.subjectDogses_ES
dc.subjectHipes_ES
dc.titleHip Osteoarthritis in Dogs: A Randomized Study Using Mesenchymal Stem Cells from Adipose Tissue and Plasma Rich in Growth Factorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ijms150813437es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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