Listar DBCFI-Artículos, capítulos... por autor "4cbebff6-20e6-4a02-9e5a-bebb9f96ae1e"

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    • Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis 

      Esteras, Raquel; Fox, Jonathan G.; Geddes, Colin C.; Mackinnon, Bruce; Ortiz, Alberto; Moreno, Juan Antonio (MDPI, 2020)
      Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria ...

    • Intravascular hemolysis triggers NAFLD characterized by a deregulation of lipid metabolism and lipophagy blockade 

      Rayego-Mateos, Sandra; Morgado-Pascual, José Luis; García-Caballero, Cristina; Lázaro, Iolanda; Sala-Vila, Aleix; Opazo-Ríos, Lucas; Mas-Fontao, Sebastián; Egido, J.; Ruiz-Ortega, Marta; Moreno, Juan Antonio (Wiley, 2023)
      Intravascular hemolysis is a common feature of different clinical entities, including sickle cell disease and malaria. Chronic hemolytic disorders are associated with hepatic damage; however, it is unknown whether heme ...

    • Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities 

      Opazo-Ríos, Lucas; Mas, Sebastián; Marín-Royo, Gema; Mezzano, Sergio; Gómez-Guerrero, Carmen; Moreno, Juan Antonio; Egido, J. (MDPI, 2020)
      Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose ...

    • Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy 

      Rayego-Mateos, Sandra; Morgado-Pascual, José Luis; Opazo-Ríos, Lucas; Guerrero-Hue, Melania; García-Caballero, Cristina; Vázquez-Carballo, Cristina; Mas, Sebastián; Sanz, Ana Belén; Herencia, Carmen; Mezzano, Sergio; Gómez-Guerrero, Carmen; Moreno, Juan Antonio; Egido, J. (MDPI, 2020)
      Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the ...

    • Preclinical Characterization of Pharmacologic NAD+Boosting as a Promising Therapeutic Approach inRheumatoid Arthritis 

      Pérez Sánchez, Carlos; Escudero Contreras, Alejandro; Cerdó, Tomás; Sánchez-Mendoza, Luz Marina; Llamas Urbano, Adrián; Arias de la Rosa, Iván; Pérez Rodríguez, Miguel; Muñoz-Barrera, Laura; Ábalos-Aguilera, María del Carmen; Barbarroja, Nuria; Calvo Gutiérrez, Jerusalém; Ortega Castro, María Rafaela; Ruiz-Vilchez, Desirée; Moreno, Juan Antonio; Burón, Isabel; González Reyes, José Antonio; López-Pedrera, Ch.; Villalba, José Manuel (Wiley, 2023)
      Objective: We analyzed NAD+ metabolism in patients with rheumatoid arthritis (RA), its association with disease activity and clinical outcomes of RA, and the therapeutic potential of pharmacologic NAD+ boosting. Methods: ...

    • Protective Role of Nrf2 in Renal Disease 

      Guerrero-Hue, Melania; Rayego-Mateos, Sandra; Vázquez-Carballo, Cristina; Palomino-Antolín, Alejandra; García-Caballero, Cristina; Opazo-Ríos, Lucas; Morgado-Pascual, José Luis; Herencia, Carmen; Mas, Sebastián; Ortiz, Alberto; Rubio-Navarro, Alfonso; Egea, Javier; Villalba, José Manuel; Egido, J.; Moreno, Juan Antonio (MDPI, 2020)
      Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. ...

    • Role of Toll-like receptor 4 in intravascular hemolysis-mediated injury 

      Vázquez-Carballo, Cristina; Herencia, Carmen; Guerrero-Hue, Melania; García-Caballero, Cristina; Rayego-Mateos, Sandra; Morgado-Pascual, José Luis; Opazo-Ríos, Lucas; González-Guerrero, Cristian; Vallejo-Mudarra, Mercedes; Cortegano, Isabel; Gaspar, María Luisa; Andrés, Belén de; Egido, J.; Moreno, Juan Antonio (Wiley, 2022)
      Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, ...

    • Semaglutide improves liver steatosis and de novo lipogenesis markers in obese and type-2-diabetic mice with metabolic-dysfunction-associated steatotic liver disease 

      Soto-Catalán, Manuel; Opazo-Ríos, Lucas; Quiceno, Hernán; Lázaro, Iolanda; Moreno, Juan Antonio; Gómez-Guerrero, Carmen; Egido, J.; Mas-Fontao, Sebastián (MDPI, 2024)
      Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent clinical condition associated with elevated morbidity and mortality rates. Patients with MASLD treated with semaglutide, a glucagon-like ...

    • Toll-Like Receptors in Acute Kidney Injury 

      Vázquez-Carballo, Cristina; Guerrero-Hue, Melania; García-Caballero, Cristina; Rayego-Mateos, Sandra; Opazo-Ríos, Lucas; Morgado-Pascual, José Luis; Herencia, Carmen; Vallejo-Mudarra, Mercedes; Cortegano, Isabel; Gaspar, María Luisa; Andrés, Belén de; Egido, J.; Moreno, Juan Antonio (MDPI, 2021)
      Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is ...