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  • Identification of novel clinical and molecular factors for the diagnosis and aggressiveness of prostate cancer 

    Gómez Gómez, Enrique (Universidad de Córdoba, UCOPress, 2019)
    Prostate cancer (PCa) is the most common solid neoplasm in men in developed countries. Unfortunately, the extraordinary heterogeneity and complexity of PCa, together with its phenotypic/clinical variability, strongly ...
  • Extra-Virgin Olive Oil Modifies the Changes Induced in Non-Nervous Organs and Tissues by Experimental Autoimmune Encephalomyelitis Models 

    Conde, Cristina; Escribano, Begoña M.; Luque, Evelio; Feijóo, Montserrat; Caballero-Villarraso, Javier; Valdelvira, Manuel E.; Ochoa Sepúlveda, Juan J.; Lillo, Rafael; Paz, Elier; Santamaría, Abel; Agüera, Eduardo; Túnez, Isaac (MDPI, 2019)
    This study reveals the existence of oxidative stress (reactive oxygen species (ROS)) in non-nervous organs and tissues in multiple sclerosis (MS) by means of a model of experimental autoimmune encephalomyelitis (EAE) in ...
  • Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features 

    Vázquez Borrego, María del Carmen; Fuentes-Fayos, Antonio C.; Venegas-Moreno, Eva; Rivero-Cortés, Esther; Dios, Elena; Moreno Moreno, Paloma; Madrazo-Atutxa, Ainara; Remón, Pablo; Solivera, Juan; Wildemberg, Luiz E.; Kasuki, Leandro; López-Fernández, Judith M.; Gadelha, Mônica R.; Gálvez-Moreno, M. Ángeles; Soto-Moreno, Alfonso; Gahete Ortiz, Manuel D.; Castaño, Justo P.; Luque, Raúl M. (MDPI, 2019)
    Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ...
  • Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice 

    Biagetti, Betina; Herance, J.R.; Ferrer, Roser; Aulinas, Anna; Palomino-Schätzlein, Martina; Mesa, Jordi; Castaño, Justo P.; Luque, Raúl M.; Simó, Rafael (MDPI, 2019)
    Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated ...
  • Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer 

    Gómez-Gómez, E.; Jiménez-Vacas, J.M.; Pedraza-Arévalo, Sergio; López-López, F.; Herrero-Aguayo, V.; Hormaechea Agulla, Daniel; Valero-Rosa, J.; Ibáñez-Costa, Alejandro; León González, A.J.; Sánchez-Sánchez, Rafael; Gónzalez Serrano, T.; Requena-Tapia, M.J.; Castaño, Justo P.; Carrasco-Valiente, J.; Gahete Ortiz, Manuel D.; Luque, R.M. (MDPI, 2019)
    Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the ...

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