• Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia 

      Valhondo, Isabel; Hassouneh, Fakhri; López-Sejas, Nelson; Pera Rojas, Alejandra; Sánchez-Correa, Beatriz; Guerrero, Beatriz; Bergua, Juan M.; Arcos, María José; Bañas, Helena; Casas-Avilés, Ignacio; Sánchez García, Joaquín; Serrano, Josefina; Martín, Carmen; Durán, Esther; Alonso, Corona; Solana Lara, Rafael; Tarazona, Raquel (MDPI, 2020)
      Background: Acute myeloid leukemia (AML) remains a major clinical challenge due to poor overall survival, which is even more dramatic in elderly patients. TIGIT, an inhibitory receptor that interacts with CD155 and CD112 ...
    • CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals 

      Pera Rojas, Alejandra; Campos Fernández, Carmen; Sánchez-Correa, Beatriz; Tarazona, Raquel; Larbi, Anis; Solana Lara, Rafael; Alonso, Corona (Public Library of Science, 2014)
      Cytomegalovirus (CMV) latent infection has a deleterious effect on the efficacy of influenza vaccination in the elderly, suggesting that CMV restricts immunological diversity impairing the immune system functionality in ...
    • DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy 

      Sánchez-Correa, Beatriz; Valhondo, Isabel; Hassouneh, Fakhri; López-Sejas, Nelson; Pera Rojas, Alejandra; Bergua, Juan M.; Arcos, María José; Bañas, Helena; Casas-Avilés, Ignacio; Durán, Esther; Alonso, Corona; Solana Lara, Rafael; Tarazona, Raquel (MDPI, 2019)
      Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals ...
    • Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets 

      Hassouneh, Fakhri; López-Sejas, Nelson; Sánchez-Correa, Beatriz; Tarazona, Raquel; Solana Lara, Rafael; Pera Rojas, Alejandra; Campos Fernández, Carmen (MDPI, 2017)
      The differential impact of ageing and cytomegalovirus (CMV) latent infection on human T-cell subsets remains to some extent controversial. The purpose of this study was to analyse the expression of the transcription factors ...