Listar DBCFI-Artículos, capítulos... por autor "f475ba68-65d2-4c31-a678-3cbc098208f2"

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    • Identification of novel genes involved in the plasticity of pituitary melanotropes in amphibians 

      Malagón, María M.; Cruz García, D.; Díaz-Ruiz Ruiz, A.; Peinado, Juan R.; Pulido, Marina R.; Araújo, J.; García Navarro, S.; Gracia-Navarro, F.; Castaño, Justo P.; Vázquez Martínez, Rafael (New York Academy os Sciences, 2009)
      Melanotrope cells from the amphibian intermediate lobe are composed of two subpopulations that exhibit opposite secretory behavior: hypersecretory and hormone-storage hyposecretory melanotropes. Isolation of these ...

    • Journal article resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways 

      Rodríguez Pacheco, F.; Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Gahete Ortiz, Manuel D.; Vaudry, Hubert; Gracia-Navarro, F.; Diéguez, Carlos; Castaño, Justo P.; Malagón, María M. (Endocrine Society, 2009)
      The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also ...

    • Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue 

      Pulido, Marina R.; Rabanal Ruiz, Yoana; Almabouada, Farid; Díaz-Ruiz, Alberto; Burrel, María A; Vázquez, María J.; Castaño, Justo P.; Kineman, Rhonda D.; Luque, Raúl M.; Diéguez, Carlos; Vázquez-Martínez, Rafael; Malagón, María M. (Society for Endocrinology, 2013)
      There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...

    • Proteomic profiling of adipose tissue from Zmpste24(-/-) Mice, a model of Lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing 

      Peinado, Juan R.; Moral Quirós, Pedro; Pulido, Marina R.; Mariño García, Guillermo; Martínez-Chantar, M.L.; Vázquez Martínez, Rafael; Pérez Freije, José María; López Ontín, Carlos; Malagón, María M. (Science Direct, 2011)
      Lipodystrophy is a major disease involving severe alterations of adipose tissue distribution and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its processing enzyme, the metalloproteinase ...

    • Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity 

      Pulido, Marina R.; Díaz-Ruiz, Alberto; Jiménez-Gómez, Yolanda; García Navarro, S.; Gracia-Navarro, F.; Tinahones, Francisco J.; López-Miranda, José; Frühbeck, Gema; Vázquez Martínez, Rafael; Malagón, María M. (PLOS, 2011)
      Lipid droplets (LDs) are organelles that coordinate lipid storage and mobilization, both processes being especially important in cells specialized in managing fat, the adipocytes. Proteomic analyses of LDs have consistently ...

    • Rab18 is reduced in pituitary tumors cusing acromegaly and its overexpression reverts growth hormone hypersecretion 

      Vázquez Martínez, Rafael; Martínez-Fuentes, Antonio J.; Pulido, Marina R.; Jiménez Reina, L.; Quintero, Ana; Leal-Cerro, Alfonso; Soto, Alfonso; Webb, Susan M.; Sucunza, Nuria; Bartumeus, Frederic; Benito-López, Pedro; Galvez-Moreno, María A.; Castaño, Justo P.; Malagón, María M. (Oxford Academic, 2008)
      Context: Rab proteins regulate the sequential steps of intracellular membrane transport. Alterations of these GTPases and their associated proteins are emerging as the underlying cause for several human diseases involving ...

    • The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes 

      Rodríguez, A; Gómez-Ambrosi, Javier; Catalán, Victoria; Rotellar, Fernando; Valentí, Víctor; Silva, Camilo; Mugueta, C.; Pulido, Marina R.; Vázquez, R.; Salvador, Javier; Malagón, María M.; Colina, I.; Frühbeck, Gema (SpringerLink, 2012)
      Aims/hypothesis Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...

    • The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity 

      Moreno-Navarrete, José María; Catalán, Victoria; Whyte, Lauren; Díaz-Arteaga, Adenis; Vázquez-Martínez, Rafael; Rotellar, Fernando; Guzmán-Ruiz, Rocío; Gómez-Ambrosi, Javier; Pulido, Marina R.; Russell, Wendy R.; Imbernón, Mónica; Ross, Ruth A.; Malagón, María M.; Diéguez, Carlos; Fernández-Real, José Manuel; Frühbeck, Gema; Nogueiras, Rubén (American Diabetes Asociation, 2012)
      GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ...

    • The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots 

      Peinado, Juan R.; Jiménez Gómez, Yolanda; Pulido, Marina R.; Ortega-Bellido, María; Díaz-López, César; Padillo, Francisco; López Miranda, José; Vazquez-Martínez, Rafael; Malagón, María M. (Wiley, 2010)
      Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ...