Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants

Abstract

Summary Preterm infants (PTs) are at greater risk for vitamin D defciency, which relates to the possibility of a higher incidence of comorbidities. Our goal was twofold, 1) to monitor vitamin D, calcium, phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-8 (MMP-8) serum levels at three-time points during hospitalization, and 2) to assess the association between 25-hydroxyvitamin D (25OHD) levels and outcomes in PTs. Methods We carried out a follow-up on 50 Caucasian PTs≤32weeks of gestational age (GA) and/or≤1500g birth weight at 28days and at 4months. PTs were divided into two subgroups for tests of association with clinical outcomes based on vitamin D defcient infants 25(OH) D cord blood levels: ≤ 20ng/ml). At an initial stage, 25(OH) D levels were determined in maternal/preterm blood samples and were compared to full term delivery infants. Results There were no diferences in 25(OH) D serum levels at birth when comparing PTs to term infants, or regard ing maternal levels. A strong positive correlation was detected between maternal and neonatal 25(OH) D serum levels among PTs and term infants (r: 0.466; p60pg/mL; group 2: vitamin D>20 and PTH