Browsing Departamento de Biología Celular, Fisiología e Inmunología by Author "62629d13-b6ac-4fda-9ff9-84e53cbe0efb"
Now showing items 1-8 of 8
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Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study
Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ... -
Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study
Río Moreno, Mercedes del; Luque, Raúl M.; Rangel Zúñiga, Oriol Alberto; Alors-Pérez, Emilia; Alcalá Díaz, Juan Francisco; Roncero-Ramos, Irene; Camargo García, A.; Gahete Ortiz, Manuel D.; López-Miranda, José; Castaño, Justo P. (MDPI, 2020)Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely ... -
Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
Herrera-Martínez, Aura D.; Gahete Ortiz, Manuel D.; Sánchez-Sánchez, Rafael; Alors-Pérez, Emilia; Pedraza-Arévalo, Sergio; Serrano-Blanch, Raquel; Martínez-Fuentes, Antonio J.; Castaño, Justo P.; Luque, Raúl M.; Gálvez-Moreno, M. Ángeles (Nature.com, 2018)Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: ... -
Molecular and Clinical Implications of Somatostatin Receptor Profile and Somatostatin Analogues Treatment in Oral Cavity Squamous Cell Carcinoma
Sanjuan-Sanjuan, Alba; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Dean Ferrer, Alicia; Gahete Ortiz, Manuel D.; Heredero-Jung, Susana; Luque, Raúl M. (MDPI, 2021)Oral squamous cell carcinoma (OSCC) incidence has increased by 50% over the last decade. Unfortunately, surgery and adjuvant radiotherapy and chemotherapy are still the mainstream modality of treatment, underscoring the ... -
Novel molecular insights on the role of splicing dysregulation in cancer
Alors-Pérez, Emilia (Universidad de Córdoba, UCOPress, 2022)Cancer and tumoral diseases represent one of most serious and complicated public health problems, being one of the leading causes of death in the world. The remarkable variety across cancer types, and the heterogeneity ... -
Peptides derived from the extracellular domain of the somatostatin receptor splicing variant 1 SST5TMD4 increase malignancy in multiple cancer cell types
Río Moreno, Mercedes del; Alors-Pérez, Emilia; Borges de Souza, Patricia; Prados González, Mª Eugenia; Castaño, Justo P.; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2019)Extracellular fragments derived from plasma membrane receptors can play relevant roles in the development/progression of tumor pathologies, thereby offering novel diagnostic or therapeutic opportunities. The truncated ... -
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Moreno Montilla, M. Trinidad; Río Moreno, Mercedes del; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Wiley, 2022)Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ... -
Splicing Machinery Is Impaired in Oral Squamous Cell Carcinomas and Linked to Key Pathophysiological Features
Sanjuan-Sanjuan, Alba; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Monserrat-Barbudo, José A.; Falguera Uceda, Mabel; Heredero-Jung, Susana; Luque, Raúl M. (MDPI, 2024)Alternative splicing dysregulation is an emerging cancer hallmark, potentially serving as a source of novel diagnostic, prognostic, or therapeutic tools. Inhibitors of the activity of the splicing machinery can exert ...