• CCN2 Binds to Tubular Epithelial Cells in the Kidney 

      Rayego-Mateos, Sandra; Morgado-Pascual, José Luis; Lavoz, Carolina; Rodrigues-Díez, Raúl R.; Márquez-Expósito, Laura; Tejera-Muñoz, Antonio; Tejedor-Santamaría, Lucía; Rubio-Soto, Irene; Marchant, Vanessa; Ruiz-Ortega, Marta (MDPI, 2022)
      Cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), is considered a fibrotic biomarker and has been suggested as a potential therapeutic target for kidney pathologies. CCN2 is a ...
    • Non-Coding RNAs in Kidney Diseases: The Long and Short of Them 

      Moreno, Juan Antonio; Hamza, Eya; Guerrero-Hue, Melania; Rayego-Mateos, Sandra; García-Caballero, Cristina; Vallejo-Mudarra, Mercedes; Metzinger, Laurent; Metzinger-Le Meuth, Valérie (MDPI, 2021)
      Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the ...
    • Protective Role of Nrf2 in Renal Disease 

      Guerrero-Hue, Melania; Rayego-Mateos, Sandra; Vázquez-Carballo, Cristina; Palomino-Antolín, Alejandra; García-Caballero, Cristina; Opazo-Ríos, Lucas; Morgado-Pascual, José Luis; Herencia, Carmen; Mas, Sebastián; Ortiz, Alberto; Rubio-Navarro, Alfonso; Egea, Javier; Villalba, José Manuel; Egido, J.; Moreno, Juan Antonio (MDPI, 2020)
      Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. ...
    • Role of Toll-like receptor 4 in intravascular hemolysis-mediated injury 

      Vázquez-Carballo, Cristina; Herencia, Carmen; Guerrero-Hue, Melania; García-Caballero, Cristina; Rayego-Mateos, Sandra; Morgado-Pascual, José Luis; Opazo-Ríos, Lucas; González-Guerrero, Cristian; Vallejo-Mudarra, Mercedes; Cortegano, Isabel; Gaspar, María Luisa; Andrés, Belén de; Egido, J.; Moreno, Juan Antonio (Wiley, 2022)
      Massive intravascular hemolysis is a common characteristic of several pathologies. It is associated with the release of large quantities of heme into the circulation, promoting injury in vulnerable organs, mainly kidney, ...
    • Toll-Like Receptors in Acute Kidney Injury 

      Vázquez-Carballo, Cristina; Guerrero-Hue, Melania; García-Caballero, Cristina; Rayego-Mateos, Sandra; Opazo-Ríos, Lucas; Morgado-Pascual, José Luis; Herencia, Carmen; Vallejo-Mudarra, Mercedes; Cortegano, Isabel; Gaspar, María Luisa; Andrés, Belén de; Egido, Jesús; Moreno, Juan Antonio (MDPI, 2021)
      Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is ...