Listar Departamento de Biología Celular, Fisiología e Inmunología por autor "c07c23c6-d35c-4241-94b6-88cc23f63657"

Mostrando ítems 1-5 de 5

    • A Straightforward Cytometry-Based Protocol for the Comprehensive Analysis of the Inflammatory Valve Infiltrate in Aortic Stenosis 

      Álvarez-Heredia, Pablo; Domínguez-del-Castillo, José Joaquín; Reina-Alfonso, Irene; Gutiérrez-González, Carmen; Hassouneh, Fakhri; Batista-Duharte, Alexander; Trujillo-Aguilera, Antonio; López-Romero, Rosalía; Muñoz, Ignacio; Pera, Alejandra (MDPI, 2023)
      Aortic stenosis (AS) is a frequent cardiac disease in old individuals, characterized by valvular calcification, fibrosis, and inflammation. Recent studies suggest that AS is an active inflammatory atherosclerotic-like ...

    • Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia 

      Valhondo, Isabel; Hassouneh, Fakhri; López-Sejas, Nelson; Pera Rojas, Alejandra; Sánchez-Correa, Beatriz; Guerrero, Beatriz; Bergua, Juan M.; Arcos, María José; Bañas, Helena; Casas-Avilés, Ignacio; Sánchez García, Joaquín; Serrano, Josefina; Martín, Carmen; Durán, Esther; Alonso, Corona; Solana Lara, Rafael; Tarazona, Raquel (MDPI, 2020)
      Background: Acute myeloid leukemia (AML) remains a major clinical challenge due to poor overall survival, which is even more dramatic in elderly patients. TIGIT, an inhibitory receptor that interacts with CD155 and CD112 ...

    • DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy 

      Sánchez-Correa, Beatriz; Valhondo, Isabel; Hassouneh, Fakhri; López-Sejas, Nelson; Pera Rojas, Alejandra; Bergua, Juan M.; Arcos, María José; Bañas, Helena; Casas-Avilés, Ignacio; Durán, Esther; Alonso, Corona; Solana Lara, Rafael; Tarazona, Raquel (MDPI, 2019)
      Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals ...

    • Functional Changes of T-Cell Subsets with Age and CMV Infection 

      Hassouneh, Fakhri; Goldeck, David; Pera, Alejandra; Heemst, Diana van; Slagboom, P. Eline; Pawelec, Graham; Solana Lara, Rafael (MDPI, 2021)
      Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is associated with the expansion of polyfunctional ...

    • Immune Checkpoint Inhibitors for Vaccine Improvements: Current Status and New Approaches 

      Batista-Duharte, Alexander; Hassouneh, Fakhri; Álvarez-Heredia, Pablo; Pera, Alejandra; Solana Lara, Rafael (MDPI, 2022)
      In recent years, the use of immune checkpoint inhibitors (ICIs) in combination with approved or experimental vaccines has proven to be a promising approach to improve vaccine immunogenicity and efficacy. This strategy seeks ...