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Molecular, cellular and endocrine-metabolic factors involved in the pathological interaction between obesity and prostate cancer: Therapeutic role of metformin
(Universidad de Córdoba, UCOPress, 2017)
La próstata es una glándula exocrina con forma oval, localizada entre la vejiga y el pene y con el tamaño de una nuez. Esta glándula representa un órgano importante dentro de los sistemas urinarios y reproductivos ya que ...
Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition
(Blackwell Publishing, 2011)
Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the central nervous ...
Role of splicing process alterations in the appearance of endocrine-metabolic diseases and tumor pathologies
(Universidad de Córdoba, UCOPress, 2019)
Global human health is currently threatened by highly prevalent diseases such as obesity, diabetes and cancer. A common hallmark shared by these endocrine-metabolic and tumor diseases is the consistent alteration of the ...
Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue
(Nature Research, 2017)
During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ...
The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
(SpringerLink, 2012)
Aims/hypothesis
Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ...
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue
(Society for Endocrinology, 2013)
There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as ...