Departamento de Biología Celular, Fisiología e Inmunología: Envíos recientes

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    • Association between Diet Quality and Risk of Type 2 Diabetes Mellitus in Patients with Coronary Heart Disease: Findings from the CORDIOPREV Study 

      Rivas García, Lorenzo; Quintana-Navarro, Gracia M.; Alcalá Díaz, Juan Francisco; Torres‑Peña, J.D.; Arenas de Larriva, Antonio P.; Rangel-Zuñiga, Oriol Alberto; López-Moreno, Alejandro; Malagón, María M.; Katsiki, Niki; Pérez Martínez, Pablo; López Miranda, José; Delgado-Lista, Javier (MDPI, 2024)
      The incidence of type 2 diabetes mellitus (T2DM) is growing in Western countries. Nutritional interventions that promote high-quality dietary patterns could help reverse this trend. We aimed to evaluate whether changes in ...

    • PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing 

      López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Río Moreno, Mercedes del; Fuentes-Fayos, Antonio C.; Lara López, Araceli; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Springer Nature, 2023)
      Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the ...

    • Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing 

      López Cánovas, Juan Luis; Hermán Sánchez, Natalia; Moreno Montilla, M. Trinidad; Río Moreno, Mercedes del; Alors-Pérez, Emilia; Sánchez-Frías, Marina; Amado-Torres, Víctor; Ciria, Rubén; Briceño Delgado, Francisco Javier; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Wiley, 2022)
      Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ...

    • Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study 

      Gahete Ortiz, Manuel D.; Río Moreno, Mercedes del; Carpio Camargo, Antonio José; Alcalá Díaz, Juan Francisco; Alors-Pérez, Emilia; Delgado-Lista, Javier; Reyes Pupo, Oscar Gabriel; Ventura, Sebastián; Pérez Martínez, Pablo; Castaño, Justo P.; López Miranda, José; Luque, Raúl M. (Elsevier, 2018)
      Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, ...

    • Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma 

      López Cánovas, Juan Luis; Río Moreno, Mercedes del; García Fernández, Helena; Jiménez-Vacas, J.M.; Moreno Montilla, M. Trinidad; Sánchez-Frías, Marina; Amado-Torres, Víctor; L-López, Fernando; Fernández Fondevila, Marcos; Ciria, Rubén; Gómez-Luque, Irene; Briceño Delgado, Francisco Javier; Nogueiras, Rubén; Mata, Manuel de la; Castaño, Justo P.; Rodríguez-Perálvarez, Manuel; Luque, Raúl M.; Gahete Ortiz, Manuel D. (Elsevier, 2020)
      Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ...