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Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells
(MDPI, 2021)
Phloretin (a flavonoid abundant in apple), has antioxidant, anti-inflammatory, and glucose-transporter inhibitory properties. Thus, it has interesting pharmacological and nutraceutical potential. Bone-marrow mesenchymal ...
Analyzing Modern Biomolecules: The Revolution of Nucleic-Acid Sequencing-Review
(MDPI, 2021)
Recent developments have revolutionized the study of biomolecules. Among them are molecular markers, amplification and sequencing of nucleic acids. The latter is classified into three generations. The first allows to ...
Hard-to-heal wound healing: superiority of hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a standard hydrogel. A randomized controlled trial
(MDPI, 2023)
Chronic wounds, especially those that are hard-to-heal, constitute a serious public-health problem. Although progress has been made in the development of wound dressings for healing, there is little high-quality evidence ...
Clinical potential of mesenchymal stem cell-derived exosomes in bone regeneration
(MDPI, 2023)
Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells. Pathologies such as osteoporosis, osteoarthritis, osteonecrosis, and traumatic fractures require effective treatments that favor bone ...
Non-specific inhibition of dipeptidyl peptidases 8/9 by dipeptidyl peptidase 4 inhibitors negatively affects mesenchymal stem cell differentiation
(MDPI, 2023)
DPP4 may play a relevant role in MSC differentiation into osteoblasts or adipocytes. Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4i), such as sitagliptin and vildagliptin, are used as antidiabetic drugs. However, vildagliptin ...
EHO-85, novel amorphous antioxidant hydrogel, containing Olea europaea leaf extract—rheological properties, and superiority over a standard hydrogel in accelerating early wound healing: a randomized controlled trial
(MDPI, 2023)
Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its ...
Comparative study of the efficacy of EHO-85, a Hydrogel containing olive tree (Olea europaea) leaf extract, in skin wound healing
(MDPI, 2023)
Olive tree (Olea europaea) leaf extract (OELE) has important antioxidant and anti-inflammatory properties, supporting its use in human clinical practice. We recently designed an amorphous hydrogel called EHO-85 (EHO indicates ...