Listar DBCFI-Artículos, capítulos... por título
Mostrando ítems 156-175 de 188
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Semaglutide improves liver steatosis and de novo lipogenesis markers in obese and type-2-diabetic mice with metabolic-dysfunction-associated steatotic liver disease
(MDPI, 2024)Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent clinical condition associated with elevated morbidity and mortality rates. Patients with MASLD treated with semaglutide, a glucagon-like ... -
Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue
(Nature Research, 2017)During their lifetime, females are subjected to different nutritional and hormonal factors that could increase the risk of obesity and associated comorbidities. From early postnatal periods until the postmenopausal phase, ... -
Simple autosomic recessive inheritance of cataplexy in fighting bulls
(Universidad de Córdoba, Servicio de Publicaciones, 1983)The problem of collapsing in the fighting bull breed was conceived from a scientific point of view beginning in the thirties when different experts (Castejón y Martínez de Arizala, Peralbo, González Garcia, etc. (8) ) tried ... -
Sistemas de gamificación pregunta-respuesta para la evaluación de competencias en el área de Fisiología
(UCOPress, 2019)El presente proyecto ha consistido en la implantación de un sistema de gamificación de preguntas y respuestas en clase con el objetivo de mejorar la motivación y el compromiso de los alumnos con el aprendizaje en las ... -
Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features and Somatostatin Analogs Resistance
(MDPI, 2022)Glioblastoma (GBM) is the most malignant and lethal brain tumor. Current standard treatment consists of surgery followed by radiotherapy/chemotherapy; however, this is only a palliative approach with a mean post-operative ... -
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
(Wiley, 2022)Introduction: Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellularmachinery controlling this process (spliceosome components and splicing factors) in ... -
Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma
(Elsevier, 2020)Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1 (SF3B1) is a crucial splicing factor that can be targeted pharmacologically (e.g. pladienolide-B). Here, we show that SF3B1 is ... -
Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness Features
(MDPI, 2019)Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance of aberrant ... -
Splicing Machinery Is Impaired in Oral Squamous Cell Carcinomas and Linked to Key Pathophysiological Features
(MDPI, 2024)Alternative splicing dysregulation is an emerging cancer hallmark, potentially serving as a source of novel diagnostic, prognostic, or therapeutic tools. Inhibitors of the activity of the splicing machinery can exert ... -
Synergistic antibacterial effects of amoxicillin and gold nanoparticles: a therapeutic option to combat antibiotic resistance
(MDPI, 2023)Compacted Au@16-mph-16/DNA-AMOX (NSi) nanosystems were prepared from amoxicillin (AMOX) and precursor Au@16-mph-16 gold nanoparticles (Ni) using a Deoxyribonucleic acid (DNA) biopolymer as a glue. The synthesized nanocarrier ... -
Terapia hormonal de GnRH y PGF2a en el puerperio del ganado vacuno de leche. I. Acción en el acortamiento del ciclo reproductivo
(Universidad de Córdoba, Servicio de Publicaciones, 1992)Gonadotrophin releasing hormone (GnRH) analogue in combination with prostaglandin F2 alpha (PGF2a) was adiministered to VT in order to determine if it hastened the recovery of ovarian activity and uterine involution during ... -
The Fusarium oxysporum gnt2, Encoding a Putative NAcetylglucosamine Transferase, Is Involved in Cell Wall Architecture and Virulence
(Public Library of Science, 2013)With the aim to decipher the molecular dialogue and cross talk between Fusarium oxysporum f.sp. lycopersci and its host during infection and to understand the molecular bases that govern fungal pathogenicity, we analysed ... -
The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
(SpringerLink, 2012)Aims/hypothesis Proinflammatory and proapoptotic cytokines such as TNF-α are upregulated in human obesity. We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and ... -
The l-α-Lysophosphatidylinositol/GPR55 system and its potential role in human obesity
(American Diabetes Asociation, 2012)GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI ... -
The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy
(PLOS, 2014)Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role ... -
The potential role of the adipokine HMGB1 in obesity and insulin resistance. Novel effects on adipose tissue biology
(Elsevier, 2021)Discovery of the adipose tissue as a major source of signaling molecules almost three decades ago set a novel physiological paradigm that paved the way for the identification of metabolic organs as endocrine organs. ... -
The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat
(Taylor & Francis, 2018)This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE). Dark Agouti 2-month old ... -
The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
(MDPI, 2020)White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT ... -
The Somatostatin Analogue Octreotide Inhibits Growth of Small Intestine Neuroendocrine Tumour Cells
(Public Library Of Science (PLOS), 2012)Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms ... -
The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots
(Wiley, 2010)Adipose tissue represents a complex tissue both in terms of its cellular composition, as it includes mature adipocytes and the various cell types comprising the stromal-vascular fraction (SVF), and in relation to the ...