Listar Departamento de Biología Celular, Fisiología e Inmunología por autor "b04b6a2c-c2a8-445e-9ad4-7fef00f2375e"
Mostrando ítems 1-9 de 9
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3-Phenylcoumarins as Inhibitors of HIV-1 Replication
Olmedo, Dionisio; Sancho, Rocío; Bedoya, Luis M.; López-Pérez, José L.; Olmo, Esther del; Muñoz, Eduardo; Gupta, Mahabir P.; San Feliciano, Arturo; Alcamí, José (MDPI, 2012)We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition ... -
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2
Prados, María E.; Correa‑Sáez, Alejandro; Correa‑Sáez, Alejandro; Unciti‑Broceta, Juan D.; Garrido Rodríguez-Córdoba, Martín; Jiménez Jiménez, C.; Mazzone, Massimiliano; Minassi, Alberto; Appendino, Giovanni; Calzado Canale, Marco Antonio; Muñoz, Eduardo (Springer, 2021)Huntington’s disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway through the ... -
Cannabidiol and Other Cannabinoids in Demyelinating Diseases
Navarrete, Carmen; García-Martín, Adela; Rolland, Alain; DeMesa, Jim; Muñoz, Eduardo (MDPI, 2021)A growing body of preclinical evidence indicates that certain cannabinoids, including cannabidiol (CBD) and synthetic derivatives, may play a role in the myelinating processes and are promising small molecules to be developed ... -
Detrimental Effect of Cannabidiol on the Early Onset of Diabetic Nephropathy in Male Mice
Carmona Hidalgo, Beatriz; García-Martín, Adela; Muñoz, Eduardo; González-Mariscal, Isabel (MDPI, 2021)Anti-inflammatory and antidiabetogenic properties have been ascribed to cannabidiol (CBD). CBD-based medicinal drugs have been approved for over a lustrum, and a boom in the commercialization of CBD products started in ... -
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice
García-Martín, Adela; Navarrete, Carmen; Garrido Rodríguez-Córdoba, Martín; Prados, María E.; Caprioglio, Diego; Appendino, Giovanni; Muñoz, Eduardo (Elsevier, 2021)Some cannabinoids showed anti-inflammatory and antifibrotic activities. EHP-101 is an oral lipidic formulation of the novel non-psychotropic cannabidiol aminoquinone VCE-004.8, which showed antifibrotic activity in murine ... -
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells
García, Víctor; Lara Chica, M. Isabel; Cantarero, Irene; Sterner, Olov; Muñoz, Eduardo; Calzado Canale, Marco Antonio (Impact Journals, 2015)Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and ... -
Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
Appel, Kurt; Muñoz, Eduardo; Navarrete, Carmen; Cruz Teno, Cristina; Biller, Andreas; Thiemann, Eva (MDPI, 2018)Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina ... -
Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-kB Pathways
Olmedo, Dionisio; López-Pérez, José L.; Olmo, Esther del; Bedoya, Luis M.; Sancho, Rocío; Alcamí, José; Muñoz, Eduardo; San Feliciano, Arturo; Gupta, Mahabir P. (MDPI, 2017)Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV ... -
Neuroprotective Effects of Betulinic Acid Hydroxamate in Intraventricular Hemorrhage-Induced Brain Damage in Immature Rats
Muñoz, Eduardo; Martínez-Orgado, José; Del Pozo, Aarón; Silva, Laura; Romero, Ángela; De Hoz-Rivera, María; Villa, María; Martínez-Vega, María; Prados, María E.; Muñoz, Eduardo; Martínez-Orgado, José (MDPI, 2022)Intraventricular hemorrhage (IVH) is an important cause of long-term disability in extremely preterm infants, with no current treatment. We aimed to study in an IVH model in immature rats the neuroprotective effect of ...