Listar Departamento de Biología Celular, Fisiología e Inmunología por título
Mostrando ítems 121-140 de 280
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Hallmarks of aging in kidney from mice submitted to genetic and nutritional intervention
(Universidad de Córdoba, UCOPress, 2020)Aging should be considered as a multifactorial phenomenon and, consequently, its study should be addressed through different experimental designs. This includes nutritional and genetic interventions. In addition, it is ... -
Hematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis
(MDPI, 2020)Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury. Although haematuria is a risk factor for the development of renal disease, no previous study has analyzed the significance of haematuria ... -
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
(Public Library Of Science (PLOS), 2012)Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase ... -
Identificación de biomarcadores de disfunción del tejido adiposo en condiciones de resistencia a insulina
(Universidad de Córdoba, UCOPress, 2022)El constante incremento de la prevalencia de la obesidad a nivel mundial, que está alcanzando dimensiones epidémicas, constituye un grave problema de salud pública, debido al desarrollo de comorbilidades graves asociadas ... -
Identificación de la heterogeneidad molecular asociada a la enfermedad cardiovascular, la evolución clínica y la respuesta terapéutica en patologías Autoinmunes Sistémicas
(Universidad de Córdoba, UCOPress, 2022)Las enfermedades autoinmunes son enfermedades multifactoriales, resultado de la interacción entre factores genéticos, factores ambientales y alteraciones del propio sistema inmune. Entre ellas, el lupus eritematoso sistémico ... -
Identificación de marcadores predictivos en cáncer y enfermedad metabólica relacionados con la ruta de respuesta a hipoxia
(Universidad de Córdoba, UCOPress, 2018)La búsqueda de nuevos marcadores predictivos en enfermedades de alta prevalencia como el cáncer o el síndrome metabólico sigue siendo a día de hoy uno de los pilares básicos en la investigación biomédica traslacional. ... -
Identificación de nuevos marcadores del tejido adiposo en relación a obesidad y resistencia a insulina
(Universidad de Córdoba, UCOPress, 2015)INTRODUCTION The adipose tissue (AT) has been long considered to play a passive role as a fat storage depot. However, recent discoveries have significantly modified the classical view of adipose tissue as an inert energy ... -
Identification of immunosenescence markers in models of cardiovascular disease, infection, and inflammatory-based diseases
(Universidad de Córdoba, UCOPress, 2024)The immune system, a complex defense system, safeguards the body from various threats. Immunosenescence, an age-related deterioration of the immune system, is characterized by the accumulation of memory T cells and the ... -
Identification of new kinase substrates involved in the DNA Damage Response pathway and its implication in carcinogenesis
(Universidad de Córdoba, UCOPress, 2017)One of the most relevant altered pathways in cancer is the DNA Damage Response (DDR), a well-coordinated network of signalling cascades that cells have developed during evolution in order to maintain genomic integrity. ... -
Identification of novel biomarkers and therapeutic targets in the pathological interaction between the dysregulation of the endocrinemetabolic system and prostate cancer
(Universidad de Córdoba, UCOPress, 2022)Obesity (OB) is a metabolic chronic disease with a growing incidence and elevated morbidities and mortality [1, 2]. OB is also associated with elevated economic costs for the health systems representing a worldwide public ... -
Identification of novel cellular and/or molecular markers involved in the pharmacological response and contributions of splicing mechanisms in pituitary tumors
(Universidad de Córdoba, UCOPress, 2019) -
Identification of novel clinical and molecular factors for the diagnosis and aggressiveness of prostate cancer
(Universidad de Córdoba, UCOPress, 2019)Prostate cancer (PCa) is the most common solid neoplasm in men in developed countries. Unfortunately, the extraordinary heterogeneity and complexity of PCa, together with its phenotypic/clinical variability, strongly ... -
Identification of novel endocrine-metabolic and splicing machinery factors with diagnostic, prognostic and/or therapeutic potential in prostate cancer
(Universidad de Córdoba, UCOPress, 2020)Prostate cancer (PCa) is the tumor pathology with the highest incidence among men in developed countries and represents one of the main causes of cancer-related death in this group. Despite the advances achieved during the ... -
Identification of novel genes involved in the plasticity of pituitary melanotropes in amphibians
(New York Academy os Sciences, 2009)Melanotrope cells from the amphibian intermediate lobe are composed of two subpopulations that exhibit opposite secretory behavior: hypersecretory and hormone-storage hyposecretory melanotropes. Isolation of these ... -
Identification of Novel Markers and Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Potential in Brain Tumors
(Universidad de Córdoba, UCOPress, 2022)Primary brain tumors represent a highly variable and heterogeneous group of neoplasms (~150 different types) that includes non-malignant and malignant tumors. The most frequent malignant brain tumors are gliomas (representing ... -
Identification of novel molecular markers and contribution of splicing mechanisms in endocrine-related tumoral pathologies
(Universidad de Córdoba, UCOPress, 2020)Cancer represents one of the main challenges for the human being, in that it encompasses some of the most severe and health-threatening pathologies worldwide. Although great efforts are being implemented and significant ... -
Identification of novel molecular markers in pituitary tumors: contribution to pathogenesis and therapeutic potential
(Universidad de Córdoba, UCOPress, 2015)Los adenomas hipofisarios se han considerado comúnmente como una patología tumoral infrecuente debido, posiblemente, a una subestimación en su diagnóstico y consecuentemente, baja incidencia; sin embargo, resultados de ... -
Identification of potential bioactive peptides in sheep milk kefir through peptidomic analysis at different fermentation times
(MDPI, 2023)Sheep farming is an important socioeconomic activity in most Mediterranean countries, particularly Spain, where it contributes added value to rural areas. Sheep milk is used in Spain mainly for making cheese, but it can ... -
Immune Checkpoint Inhibitors for Vaccine Improvements: Current Status and New Approaches
(MDPI, 2022)In recent years, the use of immune checkpoint inhibitors (ICIs) in combination with approved or experimental vaccines has proven to be a promising approach to improve vaccine immunogenicity and efficacy. This strategy seeks ... -
Immunohistochemical analysis of ß3 integrin (CD61): expression in pig tissues and human tumors
(Fundación Séneca, 2002)CD61 is a membrane glycoprotein that associates with CD41 (aIIb) to form the heterodimeric complex gpIIb/IIIa (CD41/CD61), predominantly expressed in platelets and megakariocytes. CD61 or ß3 integrin also associates ...